The endocrinology of aging
- PMID: 9334293
- DOI: 10.1126/science.278.5337.419
The endocrinology of aging
Abstract
Most aging individuals die from atherosclerosis, cancer, or dementia; but in the oldest old, loss of muscle strength resulting in frailty is the limiting factor for an individual's chances of living an independent life until death. Three hormonal systems show decreasing circulating hormone concentrations during normal aging: (i) estrogen (in menopause) and testosterone (in andropause), (ii) dehydroepiandrosterone and its sulphate (in adrenopause), and (iii) the growth hormone/insulin-like growth factor I axis (in somatopause). Physical changes during aging have been considered physiologic, but there is evidence that some of these changes are related to this decline in hormonal activity. Hormone replacement strategies have been developed, but many of their aspects remain controversial, and increasing blood hormone levels in aging individuals to those found during mid-adult life has not been uniformly proven to be safe and of benefit.
Comment in
-
Aging and endocrinology.Science. 1998 Jan 16;279(5349):305-6; author reply 306. Science. 1998. PMID: 9454318 No abstract available.
Similar articles
-
The male climacterium: clinical signs and symptoms of a changing endocrine environment.Prostate Suppl. 2000;10:2-8. doi: 10.1002/1097-0045(2000)45:10+<2::aid-pros2>3.0.co;2-y. Prostate Suppl. 2000. PMID: 11056486 Review.
-
The endocrinology of gonadal involution: menopause and andropause.Ann Endocrinol (Paris). 2003 Apr;64(2):77-81. Ann Endocrinol (Paris). 2003. PMID: 12773935 Review.
-
[Selected endocrinological problems in mature and elderly men].Ginekol Pol. 1998 Jun;69(6):367-73. Ginekol Pol. 1998. PMID: 9695345 Review. Polish.
-
[Rejuvenating hormones].Rev Med Brux. 1999 Sep;20(4):A386-91. Rev Med Brux. 1999. PMID: 10523929 French.
-
Endocrinological aspects of aging in men: is hormone replacement of benefit?Eur J Obstet Gynecol Reprod Biol. 2000 Sep;92(1):7-12. doi: 10.1016/s0301-2115(00)00420-6. Eur J Obstet Gynecol Reprod Biol. 2000. PMID: 10986428 Review.
Cited by
-
Anatomical location, sex, and age modulate adipocyte progenitor populations in perivascular adipose tissues.Front Physiol. 2024 Jul 12;15:1411218. doi: 10.3389/fphys.2024.1411218. eCollection 2024. Front Physiol. 2024. PMID: 39072214 Free PMC article.
-
Tolerability of Antihypertensive Medications: The Influence of Age.High Blood Press Cardiovasc Prev. 2024 May;31(3):261-269. doi: 10.1007/s40292-024-00639-z. Epub 2024 Apr 24. High Blood Press Cardiovasc Prev. 2024. PMID: 38658522 Free PMC article.
-
The role of supervision and motivation during exercise on physical and mental health in older adults: a study protocol for a randomized controlled trial (PRO-Training project).BMC Geriatr. 2024 Mar 20;24(1):274. doi: 10.1186/s12877-024-04868-8. BMC Geriatr. 2024. PMID: 38509514 Free PMC article.
-
Analysis of the association between testosterone and cardiovascular disease potential risk factor apolipoprotein B in adult males without cancer: national health and nutrition examination survey 2011-2016.Front Endocrinol (Lausanne). 2024 Feb 16;15:1304344. doi: 10.3389/fendo.2024.1304344. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38435750 Free PMC article.
-
Dehydroepiandrosterone Sulfate, an Adrenal Androgen, Is Inversely Associated with Prevalence of Dynapenia in Male Individuals with Type 2 Diabetes.Metabolites. 2023 Nov 3;13(11):1129. doi: 10.3390/metabo13111129. Metabolites. 2023. PMID: 37999225 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical