Comparative Study
. 1997 Dec;18(6):580-93; discussion 661-6.
doi: 10.1016/s0197-2456(97)00051-2.
Cumulating evidence from randomized trials: utilizing sequential monitoring boundaries for cumulative meta-analysis
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- PMID: 9408720
- DOI: 10.1016/s0197-2456(97)00051-2
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Comparative Study
Cumulating evidence from randomized trials: utilizing sequential monitoring boundaries for cumulative meta-analysis
Control Clin Trials.
1997 Dec.
Abstract
We propose the adaptation of classical monitoring boundaries for use in cumulative meta-analysis as guidelines for deciding when accumulating evidence is statistically significant and medically convincing. The interpretation of information from a randomized controlled trial is compared with that from a meta-analysis. The concept of optimal information size for a meta-analysis is developed and used to adapt monitoring boundaries to cumulative meta-analysis.
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