Comparative aspects on nitric oxide in brain and its role as a cerebral vasodilator
- PMID: 9505413
- DOI: 10.1016/s0300-9629(97)00024-8
Comparative aspects on nitric oxide in brain and its role as a cerebral vasodilator
Abstract
Histological studies have detected nitric oxide (NO) synthase in the central nervous system of all vertebrates examined, from lampreys to mammals. However, there are still very few comparative physiological studies on the function of NO synthase in the brain of non-mammalian vertebrates. So far, we know that acetylcholine can cause an NO-dependent increase in brain blood flow in turtles and some fish species (crucian carp and rainbow trout), whereas some other fishes appear to lack such a mechanism. Hypercapnia can induce NO-dependent cerebral vasodilation in mammals, but such a mechanism appears to be lacking in the ectothermic vertebrates examined. The number of species studied needs to be expanded before we can draw any firm conclusions about the origin of NO-dependent brain blood flow regulation: if it has evolved more than once or if it has been occasionally lost during evolution. We conclude that NO synthase may be present in all vertebrate brains but that its functions can vary, as judged from its role in cerebral blood flow regulation. The diversity of functions that NO has proven to have within the mammalian brain is likely to be paralleled by the same degree of diversity of function between vertebrate groups.
Similar articles
-
Brain blood flow during hypercapnia in fish: no role of nitric oxide.Brain Res. 2000 Feb 28;857(1-2):207-11. doi: 10.1016/s0006-8993(99)02428-2. Brain Res. 2000. PMID: 10700569
-
Nitric oxide is not the sole determinant of hypercapnic or metabolically driven vasodilation in the cerebral circulation.J Auton Nerv Syst. 1994 Sep;49 Suppl:S67-72. doi: 10.1016/0165-1838(94)90090-6. J Auton Nerv Syst. 1994. PMID: 7836690
-
Evidence that acetylcholine mediates increased cerebral blood flow velocity in crucian carp through a nitric oxide-dependent mechanism.J Cereb Blood Flow Metab. 1995 May;15(3):519-24. doi: 10.1038/jcbfm.1995.64. J Cereb Blood Flow Metab. 1995. PMID: 7536198
-
Nitric oxide and the cerebral circulation.Stroke. 1994 Mar;25(3):692-703. doi: 10.1161/01.str.25.3.692. Stroke. 1994. PMID: 7510430 Review.
-
Nitric oxide synthase inhibition and cerebrovascular regulation.J Cereb Blood Flow Metab. 1994 Mar;14(2):175-92. doi: 10.1038/jcbfm.1994.25. J Cereb Blood Flow Metab. 1994. PMID: 7509338 Review.
Cited by
-
Acid-Sensing Ion Channels: Novel Mediators of Cerebral Vascular Responses.Circ Res. 2019 Oct 25;125(10):907-920. doi: 10.1161/CIRCRESAHA.119.315024. Epub 2019 Aug 27. Circ Res. 2019. PMID: 31451088 Free PMC article.
-
Recombinant interleukin-1β dilates steelhead trout coronary microvessels: effect of temperature and role of the endothelium, nitric oxide and prostaglandins.J Exp Biol. 2015 Jul;218(Pt 14):2269-78. doi: 10.1242/jeb.119255. Epub 2015 May 29. J Exp Biol. 2015. PMID: 26026045 Free PMC article.
-
A kinetic approach to assess oxidative metabolism related features in the bivalve Mya arenaria.Theory Biosci. 2012 Dec;131(4):253-64. doi: 10.1007/s12064-012-0159-y. Epub 2012 Jul 25. Theory Biosci. 2012. PMID: 22829190
-
Mechanisms of vasodilation in the dorsal aorta of the elephant fish, Callorhinchus milii (Chimaeriformes: Holocephali).J Comp Physiol B. 2007 Jul;177(5):557-67. doi: 10.1007/s00360-007-0154-7. Epub 2007 Mar 7. J Comp Physiol B. 2007. PMID: 17342492
Publication types
MeSH terms
Substances
LinkOut - more resources
Research Materials