doi: 10.7164/antibiotics.50.1036.
Brasilinolide A, a new macrolide antibiotic produced by Nocardia brasiliensis: producing strain, isolation and biological activity
Affiliations
- PMID: 9510911
- DOI: 10.7164/antibiotics.50.1036
Item in Clipboard
Brasilinolide A, a new macrolide antibiotic produced by Nocardia brasiliensis: producing strain, isolation and biological activity
J Antibiot (Tokyo).
1997 Dec.
Free article
Abstract
A new 32-membered macrolide antibiotic, brasilinolide A was isolated from the fermentation broth of Nocardia sp. IFM 0406. The producer was identified as Nocardia brasiliensis. The antibiotic was only active against Aspergillus niger, but not active against other fungi including yeasts as well as other filamentous like fungi and bacteria. Brasilinolide A exerted an immunosuppressive activity in the assay system of a mixed lymphocyte reaction (MLR).
Similar articles
-
Brasilicardin A, a new terpenoid antibiotic from pathogenic Nocardia brasiliensis: fermentation, isolation and biological activity.J Antibiot (Tokyo). 1999 Jan;52(1):13-9. doi: 10.7164/antibiotics.52.13. J Antibiot (Tokyo). 1999. PMID: 10092191
-
PC-766B, a new macrolide antibiotic produced by Nocardia brasiliensis. I. Taxonomy, fermentation and biological activity.J Antibiot (Tokyo). 1993 Jun;46(6):972-8. doi: 10.7164/antibiotics.46.972. J Antibiot (Tokyo). 1993. PMID: 8393851
-
Absolute stereochemistry of immunosuppressive macrolide brasilinolide A and its new congener brasilinolide C.J Org Chem. 2004 Mar 5;69(5):1535-41. doi: 10.1021/jo035773v. J Org Chem. 2004. PMID: 14987008
-
Recent advances in the field of 16-membered macrolide antibiotics.Mini Rev Med Chem. 2011 Oct;11(12):1009-18. doi: 10.2174/138955711797247734. Mini Rev Med Chem. 2011. PMID: 21861810 Review.
-
Macrolides: From Toxins to Therapeutics.Toxins (Basel). 2021 May 12;13(5):347. doi: 10.3390/toxins13050347. Toxins (Basel). 2021. PMID: 34065929 Free PMC article. Review.
Cited by
-
Natural Polyketides Act as Promising Antifungal Agents.Biomolecules. 2023 Oct 24;13(11):1572. doi: 10.3390/biom13111572. Biomolecules. 2023. PMID: 38002254 Free PMC article. Review.
-
Dactylosporolides: Glycosylated Macrolides from Dactylosporangium fulvum.J Nat Prod. 2022 Dec 23;85(12):2714-2722. doi: 10.1021/acs.jnatprod.2c00484. Epub 2022 Dec 13. J Nat Prod. 2022. PMID: 36512509 Free PMC article.
-
A novel LysR-type regulator negatively affects biosynthesis of the immunosuppressant brasilicardin.Eng Life Sci. 2020 Nov 4;21(1-2):4-18. doi: 10.1002/elsc.202000038. eCollection 2021 Jan. Eng Life Sci. 2020. PMID: 33531886 Free PMC article.
-
New Nocobactin Derivatives with Antimuscarinic Activity, Terpenibactins A-C, Revealed by Genome Mining of Nocardia terpenica IFM 0406.Chembiochem. 2020 Aug 3;21(15):2205-2213. doi: 10.1002/cbic.202000062. Epub 2020 Apr 2. Chembiochem. 2020. PMID: 32196864 Free PMC article.
-
Identification and engineering of 32 membered antifungal macrolactone notonesomycins.Microb Cell Fact. 2020 Mar 19;19(1):71. doi: 10.1186/s12934-020-01328-x. Microb Cell Fact. 2020. PMID: 32192516 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
