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Review
. 1998 Mar 15;83(1-2):88-101.
doi: 10.1016/s0165-5728(97)00225-7.

Cocaine abuse and HIV-1 infection: epidemiology and neuropathogenesis

K Goodkin  1 , P Shapshak, L R Metsch, C B McCoy, K A Crandall, M Kumar, R K Fujimura, V McCoy, B T Zhang, S Reyblat, K Q Xin, A M Kumar
Affiliations
Free article
Review

Cocaine abuse and HIV-1 infection: epidemiology and neuropathogenesis

K Goodkin et al. J Neuroimmunol. .
Free article

Abstract

The epidemiology of cocaine abuse and potential relationships of cocaine withdrawal to human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) are discussed. Neuroendocrinological changes in HIV-1 infection of the central nervous system (CNS) are discussed with the relevant impact of cocaine abuse. HIV-1 load in the brain tissue of infected substance users is described along with possible associations with neuropathology and HAD. Finally, the molecular epidemiology and sequence heterogeneity of HIV-1 and their implications for neuropathogenesis are summarized. The complex context of addressing cocaine abuse in the setting of HIV-1 infection appears more tractable when decomposed into its components.

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