Review
doi: 10.1016/s0959-440x(98)80037-7.
The role of assembly in insulin's biosynthesis
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- PMID: 9631292
- DOI: 10.1016/s0959-440x(98)80037-7
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Review
The role of assembly in insulin's biosynthesis
Curr Opin Struct Biol.
1998 Apr.
Abstract
Insulin is synthesised as a single-chain precursor, preproinsulin, that contains an N-terminal signal sequence and a connecting peptide linking the A and B chains of the insulin molecule. Nascent proinsulin is directed into the regulated secretory pathway, converted to insulin and stored as microcrystals. These processes exploit assembly to the zinc-containing hexamer. Structural, chemical and genetic studies, and experiments with transgenic animals and transfected cells are providing new details about the molecular events in insulin's biosynthesis.
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