Evidence for regulation of cartilage differentiation by the homeobox gene Hoxc-8
- PMID: 9707582
- PMCID: PMC21443
- DOI: 10.1073/pnas.95.17.9956
Evidence for regulation of cartilage differentiation by the homeobox gene Hoxc-8
Abstract
Homeobox genes of the Hox class are required for proper patterning of skeletal elements, but how they regulate the differentiation of specific tissues is unclear. We show here that overexpression of a Hoxc-8 transgene causes cartilage defects whose severity depends on transgene dosage. The abnormal cartilage is characterized by an accumulation of proliferating chondrocytes and reduced maturation. Since Hoxc-8 is normally expressed in chondrocytes, these results suggest that Hoxc-8 continues to regulate skeletal development well beyond pattern formation in a tissue-specific manner, presumably by controlling the progression of cells along the chondrocyte differentiation pathway. The comparison to Hoxd-4 and Isl-1 indicates that this role in chondrogenesis is specific to proteins of the Hox class. Their capacity for regulation of cartilage differentiation suggests that Hox genes could also be involved in human chondrodysplasias or other cartilage disorders.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/21443/bin/pq1780616001.gif)
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/21443/bin/pq1780616002.gif)
![Figure 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/21443/bin/pq1780616003.gif)
![Figure 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/21443/bin/pq1780616004.gif)
Similar articles
-
Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation.Development. 2001 Sep;128(18):3543-57. doi: 10.1242/dev.128.18.3543. Development. 2001. PMID: 11566859
-
Normal proliferation and differentiation of Hoxc-8 transgenic chondrocytes in vitro.BMC Dev Biol. 2003 Apr 24;3:4. doi: 10.1186/1471-213x-3-4. Epub 2003 Apr 24. BMC Dev Biol. 2003. PMID: 12713673 Free PMC article.
-
Expression of cartilage developmental genes in Hoxc8- and Hoxd4-transgenic mice.PLoS One. 2010 Feb 2;5(2):e8978. doi: 10.1371/journal.pone.0008978. PLoS One. 2010. PMID: 20126390 Free PMC article.
-
Transcriptional control of chondrocyte fate and differentiation.Birth Defects Res C Embryo Today. 2005 Sep;75(3):200-12. doi: 10.1002/bdrc.20048. Birth Defects Res C Embryo Today. 2005. PMID: 16187326 Review.
-
Wnt influence on chondrocyte differentiation and cartilage function.DNA Cell Biol. 2005 Jul;24(7):446-57. doi: 10.1089/dna.2005.24.446. DNA Cell Biol. 2005. PMID: 16008513 Review.
Cited by
-
Identification of a Chondrocyte-Specific Enhancer in the Hoxc8 Gene.J Dev Biol. 2024 Jan 24;12(1):5. doi: 10.3390/jdb12010005. J Dev Biol. 2024. PMID: 38390956 Free PMC article.
-
Association of HOXC8 Genetic Polymorphisms with Multi-Vertebral Number and Carcass Weight in Dezhou Donkey.Genes (Basel). 2022 Nov 21;13(11):2175. doi: 10.3390/genes13112175. Genes (Basel). 2022. PMID: 36421849 Free PMC article.
-
HOX genes in stem cells: Maintaining cellular identity and regulation of differentiation.Front Cell Dev Biol. 2022 Sep 13;10:1002909. doi: 10.3389/fcell.2022.1002909. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36176275 Free PMC article. Review.
-
Analysis of copy number variation in dogs implicates genomic structural variation in the development of anterior cruciate ligament rupture.PLoS One. 2020 Dec 31;15(12):e0244075. doi: 10.1371/journal.pone.0244075. eCollection 2020. PLoS One. 2020. PMID: 33382735 Free PMC article.
-
Cross-Species RNA-Seq Study Comparing Transcriptomes of Enriched Osteocyte Populations in the Tibia and Skull.Front Endocrinol (Lausanne). 2020 Sep 24;11:581002. doi: 10.3389/fendo.2020.581002. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 33071985 Free PMC article.
References
-
- Krumlauf R. Cell. 1994;78:191–201. - PubMed
-
- Capecchi M R. Ann NY Acad Sci. 1996;785:34–37. - PubMed
-
- Horan G S B, Ramirez-Solis R, Featherstone M S, Wolgemuth D J, Bradley A, Behringer R R. Genes Dev. 1995;9:1667–1677. - PubMed
-
- Davis A P, Capecchi M R. Development (Cambridge, UK) 1996;122:1175–1185. - PubMed
-
- Favier B, Rijli F M, Fromental-Ramain C, Fraulob V, Chambon P, Dolle P. Development (Cambridge, UK) 1996;122:449–460. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials