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Neurocognitive Effect of Biased µ-Opioid Receptor Agonist Oliceridine, a Utility Function Analysis and Comparison with Morphine

Laurence Moss, M.D., Hemme Hijma, Ph.D., Mark Demitrack, M.D., Jessica Kim, M.Sc., Geert Jan Groeneveld, M.D., Ph.D., Monique van Velzen, Ph.D., Marieke Niesters, M.D., Ph.D., Erik Olofsen, Ph.D., Albert Dahan, M.D., Ph.D.

Anesthesiology. December 2023: 139(6):746–756

https://doi.org/10.1097/ALN.0000000000004758

Published: December 2023

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Articles

Advances in Reversal Strategies of Opioid-induced Respiratory Toxicity

Rutger van der Schrier, M.D., Jack D. C. Dahan, B.Sc., Martijn Boon, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Monique van Velzen, Ph.D., Marieke Niesters, M.D., Ph.D., Albert Dahan, M.D., Ph.D.

Anesthesiology. April 2022: 136(4):618–632

https://doi.org/10.1097/ALN.0000000000004096

Published: April 2022

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Articles

Functional Profile of Systemic and Intrathecal Cebranopadol in Nonhuman Primates

Huiping Ding, Ph.D., Claudio Trapella, Ph.D., Norikazu Kiguchi, Ph.D., Fang-Chi Hsu, Ph.D., Girolamo Caló, M.D., Ph.D., Mei-Chuan Ko, Ph.D.

Anesthesiology. September 2021: 135(3):482–493

https://doi.org/10.1097/ALN.0000000000003848

Published: September 2021

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Articles

Modeling the Effect of Excitation on Depth of Anesthesia Monitoring in γ-Aminobutyric Acid Type A Receptor Agonist ABP-700

Beatrijs I. Valk, M.D., Douglas J. Eleveld, Ph.D., Peter Meyer, M.D., Ph.D., Sascha Meier, M.D., Ph.D., Izaak den Daas, Ph.D., Kai van Amsterdam, M.Sc., Jason A. Campagna, M.D., Ph.D., Steven P. Sweeney, B.Sc., Anthony R. Absalom, M.B.Ch.B., F.R.C.A., M.D., Michel M. R. F. Struys, M.D., Ph.D., F.R.C.A.

Anesthesiology. January 2021: 134(1):35–51

https://doi.org/10.1097/ALN.0000000000003590

Published: January 2021

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Articles

Benefit and Risk Evaluation of Biased μ-Receptor Agonist Oliceridine versus Morphine

Albert Dahan, M.D., Ph.D., C. Jan van Dam, M.D., Marieke Niesters, M.D., Ph.D., Monique van Velzen, Ph.D., Michael J. Fossler, Pharm.D., Ph.D., Mark A. Demitrack, M.D., Erik Olofsen, Ph.D.

Anesthesiology. September 2020: 133(3):559–568

https://doi.org/10.1097/ALN.0000000000003441

Published: September 2020

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Articles

Insights into the Chemical Discovery of Remifentanil

Paul L. Feldman, Ph.D.

Anesthesiology. May 2020: 132(5):1229–1234

https://doi.org/10.1097/ALN.0000000000003170

Published: May 2020

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Articles

Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice

Daniel J. Bruce, B.A., Cristina D. Peterson, Ph.D., Kelley F. Kitto, Eyup Akgün, Ph.D., Sophia Lazzaroni, B.S., Phillip S. Portoghese, Ph.D., Carolyn A. Fairbanks, Ph.D., George L. Wilcox, Ph.D.

Anesthesiology. September 2019: 131(3):649–663

https://doi.org/10.1097/ALN.0000000000002840

Published: September 2019

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Articles

Activating α4β2 Nicotinic Acetylcholine Receptors Alleviates Fentanyl-induced Respiratory Depression in Rats

Jun Ren, Ph.D, Xiuqing Ding, M.Sc., John J. Greer, Ph.D.

Anesthesiology. June 2019: 130(6):1017–1031

https://doi.org/10.1097/ALN.0000000000002676

Published: June 2019

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Articles

Peripherally Acting μ-Opioid Receptor Agonists Attenuate Ongoing Pain-associated Behavior and Spontaneous Neuronal Activity after Nerve Injury in Rats

Vinod Tiwari, Ph.D., Michael Anderson, M.S., Fei Yang, Ph.D., Vineeta Tiwari, M.Pharm., Qin Zheng, Ph.D., Shao-Qiu He, Ph.D., Tong Zhang, M.D., Bin Shu, M.D., Xueming Chen, M.D., Shaness A. Grenald, Ph.D., Kimberly E. Stephens, Ph.D., Zhiyong Chen, Ph.D., Xinzhong Dong, Ph.D., Srinivasa N. Raja, M.D., Yun Guan, M.D., Ph.D.

Anesthesiology. June 2018: 128(6):1220–1236

https://doi.org/10.1097/ALN.0000000000002191

Published: June 2018

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Articles

μ-Opioid Receptor Agonists: Do They Have Utility in the Treatment of Acute Pain?

Thomas K. Henthorn, M.D., Susan K. Mikulich-Gilbertson, Ph.D.

Anesthesiology. May 2018: 128(5):867–870

https://doi.org/10.1097/ALN.0000000000002177

Published: May 2018

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Articles

Averting Opioid-induced Respiratory Depression without Affecting Analgesia

Albert Dahan, M.D., Ph.D., Rutger van der Schrier, M.D., Terry Smith, Ph.D., Leon Aarts, M.D., Monique van Velzen, Ph.D., Marieke Niesters, M.D., Ph.D.

Anesthesiology. May 2018: 128(5):1027–1037

https://doi.org/10.1097/ALN.0000000000002184

Published: May 2018

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Articles

Liver X Receptor α Is Involved in Counteracting Mechanical Allodynia by Inhibiting Neuroinflammation in the Spinal Dorsal Horn

Jing Xu, B.S., Yi-Wei Feng, B.S., Ling Liu, M.S., Wei Wang, B.S., Xiong-Xiong Zhong, B.S., Xu-Hong Wei, Ph.D., Xian-Guo Liu, Ph.D.

Anesthesiology. September 2017: 127(3):534–547

https://doi.org/10.1097/ALN.0000000000001718

Published: September 2017

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Articles

High Concentrations of Tranexamic Acid Inhibit Ionotropic Glutamate Receptors

Irene Lecker, Ph.D., Dian-Shi Wang, M.D., Ph.D., Kirusanthy Kaneshwaran, B.S., C. David Mazer, M.D., Beverley A. Orser, M.D., Ph.D.

Anesthesiology. July 2017: 127(1):89–97

https://doi.org/10.1097/ALN.0000000000001665

Published: July 2017

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Articles

1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4 H -indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine

Po-Kuan Chao, Ph.D., Shau-Hua Ueng, Ph.D., Li-Chin Ou, Ph.D., Teng-Kuang Yeh, Ph.D., Wan-Ting Chang, M.S., Hsiao-Fu Chang, M.S., Shu-Chun Chen, M.S., Pao-Luh Tao, Ph.D., Ping-Yee Law, Ph.D., Horace H. Loh, Ph.D., Ming-Fu Cheng, Ph.D., Jian-Ying Chuang, Ph.D., Chiung-Tong Chen, Ph.D., Chuan Shih, Ph.D., Shiu-Hwa Yeh, Ph.D.

Anesthesiology. May 2017: 126(5):952–966

https://doi.org/10.1097/ALN.0000000000001568

Published: May 2017

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Articles

Hypoxia Induces Internalization of κ-Opioid Receptor

Chunhua Xi, M.D., Xuan Liang, M.D., Chunhua Chen, M.D., Ph.D., Hasan Babazada, Ph.D., Tianzuo Li, M.D., Ph.D., Renyu Liu, M.D., Ph.D.

Anesthesiology. May 2017: 126(5):842–854

https://doi.org/10.1097/ALN.0000000000001571

Published: May 2017

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Articles

Respiratory Effects of the Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist, Cebranopadol, in Healthy Human Volunteers

Albert Dahan, M.D., Ph.D., Merel Boom, M.D., Ph.D., Elise Sarton, M.D., Ph.D., Justin Hay, Ph.D., Geert Jan Groeneveld, M.D., Ph.D., Meike Neukirchen, Ph.D., John Bothmer, Ph.D., Leon Aarts, M.D., Ph.D., Erik Olofsen, M.Sc.

Anesthesiology. April 2017: 126(4):697–707

https://doi.org/10.1097/ALN.0000000000001529

Published: April 2017

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Articles

Opioid-type Respiratory Depressant Side Effects of Cebranopadol in Rats Are Limited by Its Nociceptin/Orphanin FQ Peptide Receptor Agonist Activity

Klaus Linz, Ph.D., Wolfgang Schröder, Ph.D., Stefanie Frosch, Ph.D., Thomas Christoph, Ph.D.

Anesthesiology. April 2017: 126(4):708–715

https://doi.org/10.1097/ALN.0000000000001530

Published: April 2017

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Articles

Common Anesthetic-binding Site for Inhibition of Pentameric Ligand-gated Ion Channels

Monica N. Kinde, Ph.D., Weiming Bu, Ph.D., Qiang Chen, Ph.D., Yan Xu, Ph.D., Roderic G. Eckenhoff, M.D., Pei Tang, Ph.D.

Anesthesiology. March 2016: 124(3):664–673

https://doi.org/10.1097/ALN.0000000000001005

Published: March 2016

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Articles

5-HT 1A Receptor Agonist Befiradol Reduces Fentanyl-induced Respiratory Depression, Analgesia, and Sedation in Rats

Jun Ren, Ph.D., Xiuqing Ding, B.Sc., John J. Greer, Ph.D.

Anesthesiology. February 2015: 122(2):424–434

https://doi.org/10.1097/ALN.0000000000000490

Published: February 2015

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Articles

Blocking the Mineralocorticoid Receptor Improves Effectiveness of Steroid Treatment for Low Back Pain in Rats

Ling Ye, M.D., Wenrui Xie, Ph.D., Judith A. Strong, Ph.D., Jun-Ming Zhang, M.D., M.Sc.

Anesthesiology. September 2014: 121(3):632–643

https://doi.org/10.1097/ALN.0000000000000277

Published: September 2014

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NARROW

Neurocognitive Effect of Biased µ-Opioid Receptor Agonist Oliceridine, a Utility Function Analysis and Comparison with Morphine

Advances in Reversal Strategies of Opioid-induced Respiratory Toxicity

Functional Profile of Systemic and Intrathecal Cebranopadol in Nonhuman Primates

Modeling the Effect of Excitation on Depth of Anesthesia Monitoring in γ-Aminobutyric Acid Type A Receptor Agonist ABP-700

Benefit and Risk Evaluation of Biased μ-Receptor Agonist Oliceridine versus Morphine

Insights into the Chemical Discovery of Remifentanil

Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice

Activating α4β2 Nicotinic Acetylcholine Receptors Alleviates Fentanyl-induced Respiratory Depression in Rats

Peripherally Acting μ-Opioid Receptor Agonists Attenuate Ongoing Pain-associated Behavior and Spontaneous Neuronal Activity after Nerve Injury in Rats

μ-Opioid Receptor Agonists: Do They Have Utility in the Treatment of Acute Pain?

Averting Opioid-induced Respiratory Depression without Affecting Analgesia

Liver X Receptor α Is Involved in Counteracting Mechanical Allodynia by Inhibiting Neuroinflammation in the Spinal Dorsal Horn

High Concentrations of Tranexamic Acid Inhibit Ionotropic Glutamate Receptors

1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4 H -indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine

Hypoxia Induces Internalization of κ-Opioid Receptor

Respiratory Effects of the Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist, Cebranopadol, in Healthy Human Volunteers

Opioid-type Respiratory Depressant Side Effects of Cebranopadol in Rats Are Limited by Its Nociceptin/Orphanin FQ Peptide Receptor Agonist Activity

Common Anesthetic-binding Site for Inhibition of Pentameric Ligand-gated Ion Channels

5-HT 1A Receptor Agonist Befiradol Reduces Fentanyl-induced Respiratory Depression, Analgesia, and Sedation in Rats

Blocking the Mineralocorticoid Receptor Improves Effectiveness of Steroid Treatment for Low Back Pain in Rats

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