Authors
Martha E Shenton, Ron Kikinis, Ferenc A Jolesz, Seth D Pollak, Marjorie LeMay, Cynthia G Wible, Hiroto Hokama, John Martin, Dave Metcalf, Michael Coleman, Robert W McCarley
Publication date
1992/8/27
Journal
New England Journal of Medicine
Volume
327
Issue
9
Pages
604-612
Publisher
Massachusetts Medical Society
Description
Background
Data from postmortem, CT, and magnetic resonance imaging (MRI) studies indicate that patients with schizophrenia may have anatomical abnormalities of the left temporal lobe, but it is unclear whether these abnormalities are related to the thought disorder characteristic of schizophrenia.
Methods
We used new MRI neuroimaging techniques to derive (without knowledge of the diagnosis) volume measurements and three-dimensional reconstructions of temporal-lobe structures in vivo in 15 right-handed men with chronic schizophrenia and 15 matched controls.
Results
As compared with the controls, the patients had significant reductions in the volume of gray matter in the left anterior hippocampus—amygdala (by 19 percent [95 percent confidence interval, 3 to 36 percent]), the left parahippocampal gyrus (by 13 percent [95 percent confidence interval, 3 to 23 percent], vs. 8 percent on the right), and …
Total citations
Scholar articles
ME Shenton, R Kikinis, FA Jolesz, SD Pollak, M LeMay… - New England Journal of Medicine, 1992