Folate: metabolism, genes, polymorphisms and the associated diseases
FH Nazki, AS Sameer, BA Ganaie - Gene, 2014 - Elsevier
Folate being an important vitamin of B Complex group in our diet plays an important role not
only in the synthesis of DNA but also in the maintenance of methylation reactions in the …
only in the synthesis of DNA but also in the maintenance of methylation reactions in the …
Effects of Folate and Vitamin B12 Deficiencies During Pregnancy on Fetal, Infant, and Child Development
The importance of folate in reproduction can be appreciated by considering that the
existence of the vitamin was first suspected from efforts to explain a potentially fatal …
existence of the vitamin was first suspected from efforts to explain a potentially fatal …
[HTML][HTML] Genetics of homocysteine metabolism and associated disorders
S Brustolin, R Giugliani, TM Felix - Brazilian Journal of Medical and …, 2010 - SciELO Brasil
Homocysteine is a sulfur-containing amino acid derived from the metabolism of methionine,
an essential amino acid, and is metabolized by one of two pathways: remethylation or …
an essential amino acid, and is metabolized by one of two pathways: remethylation or …
The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men
SS Young, B Eskenazi, FM Marchetti… - Human …, 2008 - academic.oup.com
BACKGROUND Little is known about the effect of paternal nutrition on aneuploidy in sperm.
We investigated the association of normal dietary and supplement intake of folate, zinc and …
We investigated the association of normal dietary and supplement intake of folate, zinc and …
[HTML][HTML] The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defects
F Coppedè - Frontiers in genetics, 2015 - frontiersin.org
Almost 15 years ago it was hypothesized that polymorphisms of genes encoding enzymes
involved in folate metabolism could lead to aberrant methylation of peri-centromeric regions …
involved in folate metabolism could lead to aberrant methylation of peri-centromeric regions …
Association of C677T and A1298C polymorphisms of the MTHFR gene with maternal risk for Down syndrome: A meta-analysis of case-control studies
CTA Ginani, JRD da Luz, KS de Medeiros… - … Research/Reviews in …, 2023 - Elsevier
Background Several studies around the world support the hypothesis that genetic
polymorphisms involved in folate metabolism could be related to the maternal risk for Down …
polymorphisms involved in folate metabolism could be related to the maternal risk for Down …
[HTML][HTML] Analysis of seven maternal polymorphisms of genes involved in homocysteine/folate metabolism and risk of Down syndrome offspring
I Scala, B Granese, M Sellitto, S Salomè… - Genetics in …, 2006 - nature.com
PURPOSE: We present a case-control study of seven polymorphisms of six genes involved
in homocysteine/folate pathway as risk factors for Down syndrome. Gene-gene/allele-allele …
in homocysteine/folate pathway as risk factors for Down syndrome. Gene-gene/allele-allele …
MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients
N Mtiraoui, I Ezzidi, M Chaieb, H Marmouche… - Diabetes Research and …, 2007 - Elsevier
Point mutations in methylenetetrahydrofolate reductase (MTHFR) and
hyperhomocysteinemia were implicated in the pathogenesis of diabetic nephropathy (DN) in …
hyperhomocysteinemia were implicated in the pathogenesis of diabetic nephropathy (DN) in …
[HTML][HTML] The Frequency of the 677C> T and 1298A> C Polymorphisms in the Methylenetetrahydrofolate Reductase (MTHFR) Gene in the Population
Background: The gene for 5, 10-methylenetetrahydrofolate reductase (NAD (P) H) or
MTHFR gene encodes protein methylenetetrahydrofolate reductase (MTHFR), an enzyme …
MTHFR gene encodes protein methylenetetrahydrofolate reductase (MTHFR), an enzyme …
The complex relationship between folate/homocysteine metabolism and risk of Down syndrome
F Coppedè - Mutation Research/Reviews in Mutation Research, 2009 - Elsevier
Folates are essential nutrients that are required for one-carbon biosynthetic and epigenetic
processes. A deficiency in cellular folates results in aberrant DNA methylation, point …
processes. A deficiency in cellular folates results in aberrant DNA methylation, point …