miR-181a and miR-630 regulate cisplatin-induced cancer cell death
MicroRNAs (miRNA) are noncoding RNAs that regulate multiple cellular processes,
including proliferation and apoptosis. We used microarray technology to identify miRNAs …
including proliferation and apoptosis. We used microarray technology to identify miRNAs …
Synthesis, and docking studies of novel heterocycles incorporating the indazolylthiazole moiety as antimicrobial and anticancer agents
NTA Dawoud, EM El-Fakharany, AE Abdallah… - Scientific Reports, 2022 - nature.com
The current study was directed toward developing a new series of fused heterocycles
incorporating indazolylthiazole moiety. The newly synthesized compounds were …
incorporating indazolylthiazole moiety. The newly synthesized compounds were …
Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos
I Vitale, L Senovilla, M Jemaà, M Michaud… - The EMBO …, 2010 - embopress.org
Tetraploidy can constitute a metastable intermediate between normal diploidy and
oncogenic aneuploidy. Here, we show that the absence of p53 is not only permissive for the …
oncogenic aneuploidy. Here, we show that the absence of p53 is not only permissive for the …
Essential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression
Constitutive ablation of the Yin Yang 1 (YY1) transcription factor in mice results in peri-
implantation lethality. In this study, we used homologous recombination to generate …
implantation lethality. In this study, we used homologous recombination to generate …
Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5′-methylthioadenosine phosphorylase
The S-adenosylmethionine (AdoMet) salvage enzyme 5′-methylthioadenosine
phosphorylase (MTAP) has been implicated as both a cancer target and a tumor suppressor …
phosphorylase (MTAP) has been implicated as both a cancer target and a tumor suppressor …
Molecular genetics and mechanisms of apoptosis in carcinomas of the lung and pleura: therapeutic targets
LR Motadi, NL Misso, Z Dlamini, KD Bhoola - International …, 2007 - Elsevier
Cancers of the lung and pleura remain a major cause of cancer deaths, both in men and
women, with strong causal relationships between cigarette smoking and asbestos fibres …
women, with strong causal relationships between cigarette smoking and asbestos fibres …
Inhibition of Bax activity is crucial for the antiapoptotic function of the human papillomavirus E6 oncoprotein
M Vogt, K Butz, S Dymalla, J Semzow, F Hoppe-Seyler - Oncogene, 2006 - nature.com
Oncogenic types of human papillomaviruses (HPVs) cause cervical cancer in humans. The
antiapoptotic viral E6 gene has been identified as a key factor for maintaining the viability of …
antiapoptotic viral E6 gene has been identified as a key factor for maintaining the viability of …
Mitochondrial control of cell death induced by hyperosmotic stress
A Criollo, L Galluzzi, M Chiara Maiuri, E Tasdemir… - Apoptosis, 2007 - Springer
HeLa and HCT116 cells respond differentially to sorbitol, an osmolyte able to induce
hypertonic stress. In these models, sorbitol promoted the phenotypic manifestations of early …
hypertonic stress. In these models, sorbitol promoted the phenotypic manifestations of early …
Clinical significance of the p53 pathway and associated gene therapy in non-small cell lung cancers
C Huang, H Yokomise, A Miyatake - Future Oncology, 2007 - Taylor & Francis
Many molecules, including several regulators and various target genes, are involved in the
biological functions of p53, thus making the p53 pathway rather complicated. However …
biological functions of p53, thus making the p53 pathway rather complicated. However …
Selective killing of p53‐deficient cancer cells by SP600125
The genetic or functional inactivation of p53 is highly prevalent in human cancers. Using
high‐content videomicroscopy based on fluorescent TP53+/+ and TP53−/− human colon …
high‐content videomicroscopy based on fluorescent TP53+/+ and TP53−/− human colon …