Importance Magnetic resonance imaging–guided focused ultrasound ablation has been
approved for the treatment of refractory essential tremor and is being studied for other …

There are several different surgical procedures that are used to treat essential tremor (ET),
including deep brain stimulation (DBS) and thalamotomy procedures with radiofrequency …

PURPOSE: To determine if focused ultrasound beams can be used to locally open the blood-
brain barrier without damage to surrounding brain tissue and if magnetic resonance (MR) …

OBJECTIVE This work evaluated the clinical feasibility of transcranial magnetic resonance
imaging–guided focused ultrasound surgery. METHODS Transcranial magnetic resonance …

Developing minimally invasive brain surgery by high-intensity focused ultrasound beams is
of great interest in cancer therapy. However, the skull induces strong aberrations both in …

The clinical application of chemotherapy to brain tumors has been severely limited because
antitumor agents are typically unable to penetrate an intact blood‐brain barrier (BBB) …

Object Recent technological developments open the field of therapeutic application of
focused ultrasound to the brain through the intact cranium. The goal of this study was to …

OBJECTIVE Ultrasound can be precisely focused through the intact human skull to target
deep regions of the brain for stereotactic ablations. Acoustic energy at much lower …

A technique for focusing ultrasound through the human skull is described and verified. The
approach is based on a layered wavevector-frequency domain model, which propagates …

Purpose: High‐resolution vascular imaging has not been achieved in the brain due to
limitations of current clinical imaging modalities. The authors present a method for …