Non-invasive transcranial ultrasound stimulation for neuromodulation

G Darmani, TO Bergmann, KB Pauly, CF Caskey… - Clinical …, 2022 - Elsevier
Transcranial ultrasound stimulation (TUS) holds great potential as a tool to alter neural
circuits non-invasively in both animals and humans. In contrast to established non-invasive …

MRI-guided focused ultrasound surgery

FA Jolesz - Annual review of medicine, 2009 - annualreviews.org
MRI-guided focused ultrasound (MRgFUS) surgery is a noninvasive thermal ablation
method that uses magnetic resonance imaging (MRI) for target definition, treatment …

Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors

KT Chen, WY Chai, YJ Lin, CJ Lin, PY Chen… - Science …, 2021 - science.org
Focused ultrasound (FUS) in the presence of microbubbles can transiently open the blood-
brain barrier (BBB) to increase therapeutic agent penetration at the targeted brain site to …

Transcranial magnetic resonance imaging–guided focused ultrasound surgery of brain tumors: initial findings in 3 patients

N McDannold, GT Clement, P Black, F Jolesz… - …, 2010 - journals.lww.com
OBJECTIVE This work evaluated the clinical feasibility of transcranial magnetic resonance
imaging–guided focused ultrasound surgery. METHODS Transcranial magnetic resonance …

Transcranial magnetic resonance imaging–guided focused ultrasound: noninvasive central lateral thalamotomy for chronic neuropathic pain

D Jeanmonod, B Werner, A Morel, L Michels… - Neurosurgical …, 2012 - thejns.org
Object Recent technological developments open the field of therapeutic application of
focused ultrasound to the brain through the intact cranium. The goal of this study was to …

[HTML][HTML] Benchmark problems for transcranial ultrasound simulation: Intercomparison of compressional wave models

JF Aubry, O Bates, C Boehm, K Butts Pauly… - The Journal of the …, 2022 - pubs.aip.org
Computational models of acoustic wave propagation are frequently used in transcranial
ultrasound therapy, for example, to calculate the intracranial pressure field or to calculate …

500‐element ultrasound phased array system for noninvasive focal surgery of the brain: A preliminary rabbit study with ex vivo human skulls

K Hynynen, GT Clement, N McDannold… - … in Medicine: An …, 2004 - Wiley Online Library
The aim of this study was to test a prototype MRI‐compatible focused ultrasound phased
array system for trans‐skull brain tissue ablation. Rabbit thigh muscle and brain were …

Therapeutic agent delivery across the blood–brain barrier using focused ultrasound

D McMahon, MA O'Reilly… - Annual Review of …, 2021 - annualreviews.org
Specialized features of vasculature in the central nervous system greatly limit therapeutic
treatment options for many neuropathologies. Focused ultrasound, in combination with …

Acoustic properties across the human skull

TS Riis, TD Webb, J Kubanek - Ultrasonics, 2022 - Elsevier
Transcranial ultrasound is emerging as a noninvasive tool for targeted treatments of brain
disorders. Transcranial ultrasound has been used for remotely mediated surgeries, transient …

MR-guided focused ultrasound facilitates sonodynamic therapy with 5-aminolevulinic acid in a rat glioma model

SK Wu, MA Santos, SL Marcus, K Hynynen - Scientific reports, 2019 - nature.com
Glioblastoma multiforme (GBM) continues to have a dismal prognosis and significant efforts
are being made to develop more effective treatment methods. Sonodynamic therapy (SDT) …