OBJECTIVE: Studies of the neurobiological processes underlying drug addiction primarily
have focused on limbic subcortical structures. Here the authors evaluated the role of frontal …

The neural networks that putatively modulate aspects of normal emotional behavior have
been implicated in the pathophysiology of mood disorders by converging evidence from …

There is compelling evidence that the human cerebellum is engaged in a wide array of
motor and cognitive tasks. A fundamental question centers on whether the cerebellum is …

This review begins with a brief historical overview of attempts in the first half of the 20th
century to discern brain systems that underlie emotion and emotional behavior. These early …

We used event-related fMRI to assess whether brain responses to fearful versus neutral
faces are modulated by spatial attention. Subjects performed a demanding matching task for …

The application of functional neuroimaging to the study of human emotion has yielded
valuable data; however, the conclusions that may be drawn from any one study are limited …

We performed an updated quantitative meta-analysis of 162 neuroimaging studies of
emotion using a novel multi-level kernel-based approach, focusing on locating brain regions …

Although mood disorders constitute leading causes of disability, until recently little was
known about their pathogenesis. The delineation of anatomical networks that support …

Background Functional imaging studies of major depressive disorder demonstrate response-
specific regional changes following various modes of antidepressant treatment. Objective To …

The anterior cingulate cortex (ACC) ventral to the genu of the corpus callosum has been
implicated in the modulation of emotional behavior on the basis of neuroimaging studies in …