Off-label use of medication may be presented in these guidelines if a sufficient level of
evidence shows that it can be considered medically appropriate to a given condition and if …

The American Diabetes Association (ADA)“Standards of Care in Diabetes” includes the
ADA's current clinical practice recommendations and is intended to provide the components …

Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …

version of the Guidelines, which is freely available via the ESC and EAS websites and
hosted on their journals' websites (EHJ and Atherosclerosis Journal). The National Cardiac …

Summary Background The Global Burden of Diseases, Injuries, and Risk Factors Study
2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and …

Summary In 2018, the US National Institute on Aging and the Alzheimer's Association
proposed a purely biological definition of Alzheimer's disease that relies on biomarkers …

Background As mortality rates decline, life expectancy increases, and populations age, non-
fatal outcomes of diseases and injuries are becoming a larger component of the global …

The present document has been conceived as the European update to the American
College of Cardiology (ACC)/American Heart Association (AHA)/ESC 2006 Guidelines for …

Background Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the
risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that …

Background Patients with diabetes are at higher risk for death and cardiovascular outcomes
than the general population. We investigated whether the excess risk of death and …