Mechanisms behind therapeutic potentials of mesenchymal stem cell mitochondria transfer/delivery

K Malekpour, A Hazrati, S Soudi… - Journal of Controlled …, 2023 - Elsevier
Mesenchymal stromal/stem cells (MSCs) perform their therapeutic effects through various
mechanisms, including their ability to differentiate, producing different growth factors …

[HTML][HTML] CRISPR/Cas9-engineered mesenchymal stromal/stem cells and their extracellular vesicles: A new approach to overcoming cell therapy limitations

A Hazrati, K Malekpour, S Soudi… - Biomedicine & …, 2022 - Elsevier
Cell therapy is one of the newest therapeutic approaches for treating tissue destruction
diseases and replacing damaged parts in defective tissues. Among different cells …

[HTML][HTML] The effect of probiotics on immune responses and their therapeutic application: a new treatment option for multiple sclerosis

B Hashemi, M Abdollahi, S Abbaspour-Aghdam… - Biomedicine & …, 2023 - Elsevier
Multiple sclerosis (MS) is known as a chronic inflammatory disease (CID) that affects the
central nervous system and leads to nerve demyelination. However, the exact cause of MS …

Mesenchymal stem cell-derived extracellular vesicles: An emerging diagnostic and therapeutic biomolecules for neurodegenerative disabilities

M Kandeel, MA Morsy, KM Alkhodair, S Alhojaily - Biomolecules, 2023 - mdpi.com
Mesenchymal stem cells (MSCs) are a type of versatile adult stem cells present in various
organs. These cells give rise to extracellular vesicles (EVs) containing a diverse array of …

Role of Exosomes in the Pathogenesis and Theranostic of Alzheimer's Disease and Parkinson's Disease

A He, M Wang, X Li, H Chen, K Lim, L Lu… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common
neurodegenerative diseases (NDDs) threatening the lives of millions of people worldwide …

[HTML][HTML] The potential application of encapsulated exosomes: A new approach to increase exosomes therapeutic efficacy

A Hazrati, Z Mirsanei, N Heidari, K Malekpour… - Biomedicine & …, 2023 - Elsevier
Cell therapy is one of the methods that have shown promising results in treating diseases in
recent decades. However, the use of different types of cells comes with limitations. The …

Mesenchymal stem cell therapy for neurological disorders: The light or the dark side of the force?

J Isaković, K Šerer, B Barišić, D Mitrečić - Frontiers in bioengineering …, 2023 - frontiersin.org
Neurological disorders are recognized as major causes of death and disability worldwide.
Because of this, they represent one of the largest public health challenges. With awareness …

[HTML][HTML] Oleuropein reduces LPS-induced inflammation via stimulating M2 macrophage polarization

Z Mirsanei, N Heidari, A Hazrati, Y Asemani… - Biomedicine & …, 2023 - Elsevier
Oleuropein (OLEU) is the most prevalent phenolic component in olive varieties, and it has
been considered for its powerful antioxidant properties in therapeutic applications. OLEU …

Smart Nanoscale Extracellular Vesicles in the Brain: Unveiling their Biology, Diagnostic Potential, and Therapeutic Applications

A Onkar, F Khan, A Goenka… - … Applied Materials & …, 2024 - ACS Publications
Information exchange is essential for the brain, where it communicates the physiological and
pathological signals to the periphery and vice versa. Extracellular vesicles (EVs) are a …

Mesenchymal Stem Cell (MSC)-Based Drug Delivery into the Brain across the Blood–Brain Barrier

T Tashima - Pharmaceutics, 2024 - mdpi.com
At present, stem cell-based therapies using induced pluripotent stem cells (iPSCs) or
mesenchymal stem cells (MSCs) are being used to explore the potential for regenerative …