[HTML][HTML] Metabolic syndrome: updates on pathophysiology and management in 2021

G Fahed, L Aoun, M Bou Zerdan, S Allam… - International journal of …, 2022 - mdpi.com
Metabolic syndrome (MetS) forms a cluster of metabolic dysregulations including insulin
resistance, atherogenic dyslipidemia, central obesity, and hypertension. The pathogenesis …

The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited

RL Rosenfield, DA Ehrmann - Endocrine reviews, 2016 - academic.oup.com
Polycystic ovary syndrome (PCOS) was hypothesized to result from functional ovarian
hyperandrogenism (FOH) due to dysregulation of androgen secretion in 1989–1995 …

A single-cell atlas of human and mouse white adipose tissue

MP Emont, C Jacobs, AL Essene, D Pant, D Tenen… - Nature, 2022 - nature.com
White adipose tissue, once regarded as morphologically and functionally bland, is now
recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of …

[HTML][HTML] Ultra-processed diets cause excess calorie intake and weight gain: an inpatient randomized controlled trial of ad libitum food intake

KD Hall, A Ayuketah, R Brychta, H Cai, T Cassimatis… - Cell metabolism, 2019 - cell.com
We investigated whether ultra-processed foods affect energy intake in 20 weight-stable
adults, aged (mean±SE) 31.2±1.6 years and BMI= 27±1.5 kg/m 2. Subjects were admitted to …

[HTML][HTML] Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection

L Montefusco, M Ben Nasr, F D'Addio, C Loretelli… - Nature …, 2021 - nature.com
Patients with coronavirus disease 2019 (COVID-19) are reported to have a greater
prevalence of hyperglycaemia. Cytokine release as a consequence of severe acute …

[HTML][HTML] EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

European Association for the Study of The Liver… - Obesity facts, 2016 - karger.com
The Clinical Practice Guidelines (CPG) propose recommendations for the diagnosis,
treatment and follow-up of non-alcoholic fatty liver disease (NAFLD) patients and are the …

Human gut microbes impact host serum metabolome and insulin sensitivity

HK Pedersen, V Gudmundsdottir, HB Nielsen… - Nature, 2016 - nature.com
Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2
diabetes. Here we show how the human gut microbiome impacts the serum metabolome …

Richness of human gut microbiome correlates with metabolic markers

E Le Chatelier, T Nielsen, J Qin, E Prifti, F Hildebrand… - Nature, 2013 - nature.com
We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we
report the human gut microbial composition in a population sample of 123 non-obese and …

[HTML][HTML] Randomized controlled trial for time-restricted eating in healthy volunteers without obesity

Z Xie, Y Sun, Y Ye, D Hu, H Zhang, Z He… - Nature …, 2022 - nature.com
Time-restricted feeding (TRF) improves metabolic health. Both early TRF (eTRF, food intake
restricted to the early part of the day) and mid-day TRF (mTRF, food intake restricted to the …

Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches

D Kellar, S Craft - The Lancet Neurology, 2020 - thelancet.com
Insulin is a peptide secreted by the pancreas and plays an important role in the regulation of
glucose metabolism in peripheral tissues. Although the role of insulin in the periphery is well …