The concept of cognitive impairment intervening between normal ageing and very early
dementia has been in the literature for many years. Recently, the construct of mild cognitive …

The field of aging and dementia is focusing on the characterization of the earliest stages of
cognitive impairment. Recent research has identified a transitional state between the …

In this study, we have assessed the validity and reliability of an automated labeling system
that we have developed for subdividing the human cerebral cortex on magnetic resonance …

We present a technique for automatically assigning a neuroanatomical label to each voxel in
an MRI volume based on probabilistic information automatically estimated from a manually …

The NINCDS–ADRDA and the DSM-IV-TR criteria for Alzheimer's disease (AD) are the
prevailing diagnostic standards in research; however, they have now fallen behind the …

Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a longitudinal multisite
observational study of healthy elders, mild cognitive impairment (MCI), and Alzheimer's …

As we grow older, we may grow wiser, but we can also experience memory loss and
cognitive slowing that can interfere with our daily routines. The cognitive neuroscience of …

In the past 10 years, there has been a virtual explosion in the literature concerning the
construct of mild cognitive impairment. The interest in this topic demonstrates the increasing …

We present a set of techniques for embedding the physics of the imaging process that
generates a class of magnetic resonance images (MRIs) into a segmentation or registration …

A New York Times Notable Book: A psychologist's “gripping and thought-provoking” look at
how and why our brains sometimes fail us (Steven Pinker, author of How the Mind Works). In …