Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby
cytosolic materials are sequestered in a double-membrane autophagosome and …

The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for
degradation. Here we consider its roles in neuronal health and disease. We review …

Autophagy refers to the process involving the decomposition of intracellular components via
lysosomes. Autophagy plays an important role in maintaining and regulating cell …

Autophagy in Human Diseases Autophagy is a complex process of intracellular degradation
of senescent or malfunctioning organelles. Dysregulated autophagy is associated with …

Dopamine metabolism, alpha-synuclein pathology, and iron homeostasis have all been
implicated as potential contributors to the unique vulnerability of substantia nigra …

Cerebellar reserve refers to the capacity of the cerebellum to compensate for tissue damage
or loss of function resulting from many different etiologies. When the inciting event produces …

Maintaining mitochondrial health is emerging as a keystone in aging and associated
diseases. The selective degradation of mitochondria by mitophagy is of particular …

Remodeling of cytoskeleton structures, such as microtubule assembly, is believed to be
crucial for growth cone initiation and regrowth of injured axons. Autophagy plays important …