The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Cells are constantly exposed to a large variety of lipids. Traditionally, these molecules were
thought to serve as simple energy storing molecules. More recently it has been realized that …

Nuclear receptors (NRs) are ligand-dependent transcription factors whose activation affects
genes controlling vital processes. Among them, the peroxisome proliferator-activated …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Chronic kidney disease (CKD) represents a leading cause of death in the United States.
There is no cure for this disease, with current treatment strategies relying on blood pressure …

Epigenetic regulation of gene expression is strongly influenced by the accessibility of
nucleosomal DNA or the state of chromatin compaction. In this context, coregulators …

The peroxisome proliferator-activated receptors, PPARα, PPARβ, and PPARγ, are a family of
transcription factors activated by a diversity of molecules including fatty acids and fatty acid …

Tenascin-C (TNC) is a large extracellular matrix glycoprotein classified as a matricellular
protein that is generally upregulated at high levels during physiological and pathological …

Lipid metabolism has emerged as an important modulator of innate and adaptive immune
cell fate and function. The lipid‐activated transcription factors peroxisome proliferator …

Cerebral vascular endothelial cell (CEC) degeneration significantly contributes to blood–
brain barrier (BBB) breakdown and neuronal loss after cerebral ischemia. Recently …