Abnormal folate/homocysteine metabolism due to polymorphisms in genes involved in this
pathway has been implicated as an etiologic factor in Down syndrome (DS). This case …

Maternal impairments in folate metabolism and elevated homocysteinemia are known risk
factors for having a child with Down syndrome (DS) at a young age. The 80G> A …

The aetiology of non‐syndromic cleft lip with or without cleft palate (CL/P) is very complex. It
has been shown that polymorphic variants of genes encoding key proteins of folate and …

Abstract Down's syndrome (DS), a chromosomal disorder due to trisomy 21, results mostly
from nondisjunction in maternal meiosis. The present case-control study examined the …

OBJECTIVES: MTHFR C677T and A1298C have been associated with the risk of having an
infant with Down syndrome (DS), but results were conflicting. We performed this meta …

Folate is an important vitamin that contributes to cell division and growth and is therefore of
particular importance during infancy and pregnancy. Folate deficiency has been associated …

Background Migraine is a common neurovascular condition that may be linked to
hyperhomocysteinemia. We have previously provided evidence that reduction of …

The aim of the present study was to investigate the effect of polymorphisms C677T and
A1298C in the methylenetetrahydrofolate reductase (MTHFR) gene, A2756G in methionine …

Down syndrome (DS) is the most common chromosomal abnormality. Many studies have
assessed the association between maternal gene polymorphisms involved in folate …

Studies on the structure of the methylenetetrahydrofolate reductase (MTHFR) gene and the
mechanisms by which folate may reduce homocysteine levels in bacteria and in humans …