Starting at the beginning, middle, and end: translation initiation in eukaryotes

AB Sachs, P Sarnow, MW Hentze - Cell, 1997 - cell.com
AB Sachs, P Sarnow, MW Hentze
Cell, 1997cell.com
Alan B. Sachs,* Peter Sarnow,† studies, which are covered in more detail below, these and
Matthias W. Hentze‡ current models fail to fully explain this early stage of* Department of
Molecular and Cell Biology translation initiation. This review will discuss recent find-
University of California at Berkeley ings that implicate different ways by which the 40S small
Berkeley, California 94720 ribosomal subunit can be recruited to eukaryotic mRNA†
Department of Microbiology and Immunology and the various ways this recruitment step can …
Alan B. Sachs,* Peter Sarnow,† studies, which are covered in more detail below, these and Matthias W. Hentze‡ current models fail to fully explain this early stage of* Department of Molecular and Cell Biology translation initiation. This review will discuss recent find-University of California at Berkeley ings that implicate different ways by which the 40S small Berkeley, California 94720 ribosomal subunit can be recruited to eukaryotic mRNA† Department of Microbiology and Immunology and the various ways this recruitment step can be regu-Stanford University School of Medicine lated. It will then present an integrated model of the 40S Stanford, California 94305 subunit recruitment step.‡ Gene Expression Programme
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