2013 Help me understand this report
Cell-specific in vivo functions of glycosphingolipids: Lessons from genetic deletions of enzymes involved in glycosphingolipid synthesis
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Cited by 61 publications
(35 citation statements)
References 193 publications
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“…"Sphingolipidomic" analysis is now becoming feasible, at least for ceramides and other bioactive sphingolipid backbones, using MS ( 48 ), including novel MALDI MS imaging techniques ( 49 ). GSLs are believed to be involved in many cellular events such as traffi cking, signaling, and cellular interaction ( 50 ), as well as infl ammation ( 51 ). They function as important components in keratinocytes, for instance, where preservation of the skin barrier depends on GSL biosynthesis, and in enterocytes of the small intestine, where GSLs are involved in endocytosis and vesicular transport ( 50 ).…”
Section: Cell Cytotoxicity Assaymentioning
confidence: 99%
“…"Sphingolipidomic" analysis is now becoming feasible, at least for ceramides and other bioactive sphingolipid backbones, using MS ( 48 ), including novel MALDI MS imaging techniques ( 49 ). GSLs are believed to be involved in many cellular events such as traffi cking, signaling, and cellular interaction ( 50 ), as well as infl ammation ( 51 ). They function as important components in keratinocytes, for instance, where preservation of the skin barrier depends on GSL biosynthesis, and in enterocytes of the small intestine, where GSLs are involved in endocytosis and vesicular transport ( 50 ).…”
Section: Cell Cytotoxicity Assaymentioning
confidence: 99%
“…GSLs are believed to be involved in many cellular events such as traffi cking, signaling, and cellular interaction ( 50 ), as well as infl ammation ( 51 ). They function as important components in keratinocytes, for instance, where preservation of the skin barrier depends on GSL biosynthesis, and in enterocytes of the small intestine, where GSLs are involved in endocytosis and vesicular transport ( 50 ). In particular, they participate in the formation of lipid rafts, which are considered to be functional nanoscale membrane domains enriched in cholesterol and sphingolipids, characteristic of the external leafl et of cell membranes in particular ( 52 ).…”
Section: Cell Cytotoxicity Assaymentioning
confidence: 99%
“…Examination of these conditional knockout mice revealed that GlcCer synthesis has tissue-specific functions; some tissues require GlcCer synthesis, whereas others, like liver, do not. For a more detailed discussion of GlcCer function, please see the following recent review articles: [4,55]. In the present review, we focus on the role of GlcCer, as revealed by invertebrate model animals.…”
Section: Functions Of Glccermentioning
confidence: 99%
“…Glycosphingolipids (GSLs) belong to the structurally very diverse group of sphingolipids (1-3) and are not just structural elements of cells but also participate in intra-and extracellular signaling (4)(5)(6)(7)(8)(9)(10).…”
Section: Introductionmentioning
confidence: 99%
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