Investigation of the Efficacy of Adjunctive Therapy with Bioavailability‐Boosted Curcuminoids in Major Depressive Disorder

Panahi, Yunes; Badeli, Roghayeh; Karami, Gholamreza; Sahebkar, Amirhossein

doi:10.1002/ptr.5211

Cited by 148 publications

(101 citation statements)

References 48 publications

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“…In a 6-week, double-blind, placebo controlled study, Yu and colleagues (2015) demonstrated greater antidepressant effects of curcumin (1,000mg/day of a standard curcumin extract) compared to placebo. In another study, the adjunct administration of 1,000mg of curcumin to antidepressant treatment enhanced treatment gains compared to antidepressant treatment alone (Panahi et al, 2015). However, this study was flawed by its open-label design.…”

Section: Discussionmentioning

confidence: 99%

“…In a recent study by Talaei and colleagues (2015) it was demonstrated that crocin, the active constituent in saffron, augmented pharmaceutical antidepressant outcomes. Inconsistent findings have been reported with the adjunct use of curcumin and antidepressants, as evidenced by one positive (Panahi et al, 2015) and two negative studies (Bergman et al, 2013;Sanmukhani et al, 2014). However, these studies contained significant study design flaws.…”

Section: Limitations and Directions For Future Researchmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study

Lopresti

Drummond

2017

Journal of Affective Disorders

123

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Several studies have supported the antidepressant effects of curcumin (from the spice turmeric) and saffron for people with major depressive disorder. However, these studies have been hampered by poor designs, small sample sizes, short treatment duration, and similar intervention dosages. Furthermore, the antidepressant effects of combined curcumin and saffron administration are unknown.

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Section: Discussionmentioning

confidence: 99%

Section: Limitations and Directions For Future Researchmentioning

confidence: 99%

Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study

Lopresti

Drummond

2017

Journal of Affective Disorders

123

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“…The safety and efficacy of curcumin for the treatment of human diseases have been confirmed in several randomized controlled trials [13][14][15][16]17,18]. Owing to its interaction with several biological targets involved in both inflammatory processes and different stages of tumor cell proliferation, this polyphenol exhibits many pleiotropic effects relevant to the treatment of human cancers [19].…”

Section: Anti-cancer Properties Of Curcuminmentioning

confidence: 92%

Impact of curcumin on the regulation of microRNAs in colorectal cancer

Simental‐Mendía

Caraglia

Majeed

et al. 2016

Expert Review of Gastroenterology & Hepatology

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“…The other two curcuminoids namely demethoxycurcumin and bisdemethoxycurcumin also possess antioxidant activity [11]. The effectiveness of curcuminoids as an anti-depressive agent [12] and in wound healing [13] has also been proved. The safety of the Curcuma longa has been studied in various animal models [14,15] and it is clear that turmeric is not toxic even at high doses in laboratory animals.…”

Section: Introductionmentioning

confidence: 99%