In utero exposure to arsenic in tap water and congenital anomalies: A French semi-ecological study

Marie, Cécile; Léger, Stéphanie; Guttmann, Aline; Marchiset, Nathalie; Rivière, Olivier; Perthus, Isabelle; Lémery, D.; Vendittelli, Françoise; Sauvant-Rochat, Marie-Pierre

doi:10.1016/j.ijheh.2018.07.012

Cited by 12 publications

(22 citation statements)

References 35 publications

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“…Hazardous air pollutants (carbon monoxide, nitrogen dioxide, ozone, and sulfur dioxide), benzene, and particulate matter (PM) have all been associated with various birth defects, including oral cleft (cleft palate and cleft lip with and without cleft palate) and neural tube defects (Foster et al, 2017; Gilboa et al, 2005; Lupo et al, 2011; Padula et al, 2017; Stingone et al, 2014; Zhou et al, 2017; Zhu et al, 2015). The associations with the water domain are consistent with previous findings of water contaminants and birth defects (Blaidsell et al, 2019; Brender et al, 2013; Cedergren et al, 2002; Foster et al, 2017; Grazuleviciene et al, 2013; Marie et al, 2018; Rudani et al, 2014; Sanders et al, 2014; Wright et al, 2017). Studies have also shown that differences in sociodemographic factors, including race/ethnicity, are associated with increased prevalence of birth defects (Canfield et al, 2006; Padula et al, 2017; Vrijheid et al, 2000; Wang et al, 2015).…”

Section: Discussionsupporting

confidence: 88%

“…To our knowledge, this was the first study to utilize indices of overall and domain‐specific environmental quality to explore the associations of cumulative environmental exposures on the prevalence of selected birth defects. Most studies examine a single environmental exposure in association with these birth defects (Blaidsell et al, 2019; Brender et al, 2013; Grazuleviciene et al, 2013; Lupo et al, 2011; Marie et al, 2018; Rappazzo et al, 2016; Rocheleau et al, 2015; Rudani et al, 2014; Wright et al, 2017). When studies have assessed multiple pollutants, they are confined to one environmental domain (e.g., air) (Cedergren et al, 2002; Gilboa et al, 2005; Brender et al, 2008; Sanders et al, 2014; Stingone et al, 2014; Zhu et al, 2015; Zhou et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…There is robust epidemiologic literature exploring the relationships between various birth defects and environmental exposures, including air, land, sociodemographic and water environments (Blaidsell, Turyk, Almberg, Jones, & Stayner, 2019; Brender et al, 2013; Brender, Zhan, Langlois, Suarez, & Scheuerle, 2008; Canfield et al, 2006; Cedergren, Selbing, Löfman, & Källen, 2002; Foster et al, 2017; Gilboa et al, 2005; Grazuleviciene, Kapustinskiene, Vencloviene, Buinauskiene, & Nieuwenhuijsen, 2013; Luben et al, 2009; Lupo et al, 2011; Marie et al, 2018; Messer et al, 2010; Padula et al, 2017; Rappazzo et al, 2016; Rocheleau et al, 2015; Rudani et al, 2014; Sanders et al, 2014; Spinder et al, 2017; Stingone et al, 2014; Vrijheid et al, 2000; Waller, Paul, Peterson, & Hitti, 2010; Wang et al, 2015; Wright, Evans, Kaufman, Rivera‐Núñez, & Narotsky, 2017; Zhou et al, 2017; Zhu et al, 2015). However, the majority of these studies examine only a single pollutant occurring in a single environmental domain.…”

Section: Introductionmentioning

confidence: 99%

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Associations between cumulative environmental quality and ten selected birth defects in Texas

Krajewski

Rappazzo

Langlois

et al. 2020

Birth Defects Research

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BackgroundCauses of most birth defects are largely unknown. Genetics, maternal factors (e.g., age, smoking) and environmental exposures have all been linked to some birth defects, including neural tube, oral cleft, limb reduction, and gastroschisis; however, the contribution of cumulative exposures across several environmental domains in association with these defects is not well understood.MethodsThe Environmental Quality Index (EQI) and its domains (air, water, land, sociodemographic, built) were used to estimate county‐level cumulative environmental exposures from 2006–2010 and matched to birth defects identified from Texas Birth Defects Registry and live birth records from births in years 2007–2010 (N = 1,610,709). Poisson regression models estimated prevalence ratios (PR) and 95% confidence intervals (CI) for associations between 10 birth defects and the EQI.ResultsWe observed some positive associations between worst environmental quality and neural tube, anencephaly, spina bifida, oral cleft, cleft palate, cleft lip with and without cleft palate, and gastroschisis [PR range: 1.12–1.55], but near null associations with limb reduction defects. Among domain specific results, we observed the strongest positive associations with the sociodemographic domain across birth defects but varied positive associations among the air and water domains, and negative or null associations with the land and built domains. Overall, few exposure‐response patterns were evident.ConclusionsOur results highlight the complexities of cumulative, simultaneous environmental exposures in the prevalence rates of 10 selected birth defects. We were able to explore the impact of overall and domain specific environmental quality on birth defects and identify potential domain specific drivers of these associations.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations between cumulative environmental quality and ten selected birth defects in Texas

Krajewski

Rappazzo

Langlois

et al. 2020

Birth Defects Research

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“…Among the CVD studies, 21 studies found a gender-based association with drinking water contaminated with arsenic, magnesium, and calcium. With regards to children, there were higher rates of arsenic-related congenital heart anomalies and cardiovascular deaths among girls (Marie et al, 2018;Rahman et al, 2013). While women were more likely to develop abnormal cardiac rhythms (QT elongation) due to chronic arsenic exposure in drinking water (Mumford et al, 2007;Chen et al, 2013), there were overall higher rates of sudden cardiac death, ischemic heart disease, and carotid atherosclerosis among men (Bernardi et al, 1995;Nerbrand et al, 1992;Huang et al, 2009;Wang et al, 2007) due to magnesium and calcium contamination in drinking water.…”

Section: Healthmentioning

confidence: 99%

Drinking water and the implications for gender equity and empowerment: A systematic review of qualitative and quantitative evidence

Guzman

Stone

Yang

et al. 2023

International Journal of Hygiene and Environmental Health

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“…Furthermore, some animal studies have reported birth defects in offspring following maternal high-dose inorganic arsenic exposure (1) . Several human studies were identified that examined maternal arsenic exposure from a variety of sources and birth defects in offspring (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) . However, only one study reported associations specific to arsenic exposure in diet, and this study was limited to associations with orofacial clefts (OFC) (17) .…”

mentioning

confidence: 99%

Pre-pregnancy exposure to arsenic in diet and non-cardiac birth defects

Suhl

Conway²,

Rhoads³

et al. 2022

Public Health Nutr.

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Objectives: To explore associations between maternal pre-pregnancy exposure to arsenic in diet and non-cardiac birth defects. Design: Population-based, case-control study using maternal responses to a dietary assessment and published arsenic concentration estimates in food items to calculate average daily total and inorganic arsenic exposure during the year before pregnancy. Assigning tertiles of total and inorganic arsenic exposure, logistic regression analysis was used to estimate odds ratios for middle and high tertiles, compared to the low tertile. Setting: US National Birth Defects Prevention Study, 1997-2011. Participants: Mothers of 10,446 children without birth defects and 14,408 children diagnosed with a non-cardiac birth defect. Results: Maternal exposure to total dietary arsenic in the middle and high tertiles was associated with a threefold increase in cloacal exstrophy, with weak positive associations (1.2-1.5) observed either in both tertiles (intercalary limb deficiency) or the high tertile only (encephalocele, glaucoma/anterior chamber defects, bladder exstrophy). Maternal exposure to inorganic arsenic showed mostly weak, positive associations in both tertiles (colonic atresia/stenosis, esophageal atresia, bilateral renal agenesis/hypoplasia, hypospadias, cloacal exstrophy, gastroschisis), or the high (glaucoma/anterior chamber defects, choanal atresia, intestinal atresia stenosis) or middle (encephalocele, intercalary limb deficiency, transverse limb deficiency) tertiles only. The remaining associations estimated were near the null or inverse. Conclusions: This exploration of arsenic in diet and non-cardiac birth defects produced several positive, but mostly weak associations. Limitations in exposure assessment may have resulted in exposure misclassification. Continued research with improved exposure assessment is recommended to identify if these associations are true signals or chance findings.

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In utero exposure to arsenic in tap water and congenital anomalies: A French semi-ecological study

Cited by 12 publications

References 35 publications

Associations between cumulative environmental quality and ten selected birth defects in Texas

Associations between cumulative environmental quality and ten selected birth defects in Texas

Drinking water and the implications for gender equity and empowerment: A systematic review of qualitative and quantitative evidence

Pre-pregnancy exposure to arsenic in diet and non-cardiac birth defects

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