User profiles for Bradley T. Webb
![]() | Bradley T. WebbRTI International Verified email at rti.org Cited by 38450 |
Biological insights from 108 schizophrenia-associated genetic loci
…, J Waddington, D Walsh, D Wang, Q Wang, BT Webb… - Nature, 2014 - nature.com
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …
alleles, including common alleles of small effect that might be detected by genome-wide …
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Intelligence is highly heritable 1 and a major determinant of human health and well-being 2
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …
[HTML][HTML] Genetic variation in the 6p22. 3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia
…, Y Jiang, CJ MacLean, Y Ma, BT Webb… - The American Journal of …, 2002 - cell.com
Prior evidence has supported the existence of multiple susceptibility genes for schizophrenia.
Multipoint linkage analysis of the 270 Irish high-density pedigrees that we have studied, as …
Multipoint linkage analysis of the 270 Irish high-density pedigrees that we have studied, as …
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …
architecture or its genetic relationship with other disorders. To discover loci associated …
[HTML][HTML] A large-scale genome-wide association study meta-analysis of cannabis use disorder
Background Variation in liability to cannabis use disorder has a strong genetic component (estimated
twin and family heritability about 50–70%) and is associated with negative …
twin and family heritability about 50–70%) and is associated with negative …
A potential vulnerability locus for schizophrenia on chromosome 6p24–22: evidence for genetic heterogeneity
…, J Burke, B Murphy, F Duke, R Shinkwin, BT Webb… - Nature …, 1995 - nature.com
In 265 Irish pedigrees, with linkage analysis we find evidence for a vulnerability locus for
schizophrenia in region 6p24–22. The greatest lod score, assuming locus heterogeneity, is …
schizophrenia in region 6p24–22. The greatest lod score, assuming locus heterogeneity, is …
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
…, D Walsh, D Wang, Q Wang, BT Webb… - Nature …, 2016 - nature.com
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and
function differ, on average, between people with schizophrenia and healthy individuals. As …
function differ, on average, between people with schizophrenia and healthy individuals. As …
A genome-wide analysis of liberal and conservative political attitudes
The assumption that the transmission of social behaviors and political preferences is purely
cultural has been challenged repeatedly over the last 40 years by the combined evidence of …
cultural has been challenged repeatedly over the last 40 years by the combined evidence of …
Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss
Prestin, a membrane protein that is highly and almost exclusively expressed in the outer
hair cells (OHCs) of the cochlea, is a motor protein which senses membrane potential and …
hair cells (OHCs) of the cochlea, is a motor protein which senses membrane potential and …
Complement genes contribute sex-biased vulnerability in diverse disorders
…, J Waddington, D Walsh, D Wang, Q Wang, BT Webb… - Nature, 2020 - nature.com
Many common illnesses, for reasons that have not been identified, differentially affect men
and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) and …
and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) and …