User profiles for Danielle Posthuma
![]() | D PosthumaVU University & VU University Medical Centre Verified email at vu.nl Cited by 87612 |
The association between brain volume and intelligence is of genetic origin
exposure to relevant environmental experience is under strong genetic control. The subjects
for whom MRI scans were available partly overlapped with a sample of extended twin …
for whom MRI scans were available partly overlapped with a sample of extended twin …
Theory and practice in quantitative genetics
D Posthuma, AL Beem, EJC De Geus… - Twin Research and …, 2003 - cambridge.org
With the rapid advances in molecular biology, the near completion of the human genome,
the development of appropriate statistical genetic methods and the availability of the …
the development of appropriate statistical genetic methods and the availability of the …
Meta-analysis of the heritability of human traits based on fifty years of twin studies
…, A Van Bochoven, PM Visscher, D Posthuma - Nature …, 2015 - nature.com
Despite a century of research on complex traits in humans, the relative importance and specific
nature of the influences of genes and environment on human traits remain controversial. …
nature of the influences of genes and environment on human traits remain controversial. …
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease
Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …
A note on the statistical power in extended twin designs
D Posthuma, DI Boomsma - Behavior genetics, 2000 - Springer
The power to detect sources of genetic and environmental variance varies with sample size,
study design, effect size and the statistical significance level chosen. We explored whether …
study design, effect size and the statistical significance level chosen. We explored whether …
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …
Quantitative genetic modeling of variation in human brain morphology
The degree to which individual variation in brain structure in humans is genetically or
environmentally determined is as yet not well understood. We studied the brains of 54 monozygotic …
environmentally determined is as yet not well understood. We studied the brains of 54 monozygotic …
[HTML][HTML] Functional mapping and annotation of genetic associations with FUMA
…, E Taskesen, A Van Bochoven, D Posthuma - Nature …, 2017 - nature.com
A main challenge in genome-wide association studies (GWAS) is to pinpoint possible causal
variants. Results from GWAS typically do not directly translate into causal variants because …
variants. Results from GWAS typically do not directly translate into causal variants because …
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Intelligence is highly heritable 1 and a major determinant of human health and well-being 2
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …
Heritability of life satisfaction in adults: A twin-family study
Background. Subjective well-being (SWB) can be partitioned into the components life satisfaction
and affect. Research on factors influencing these components of well-being has mainly …
and affect. Research on factors influencing these components of well-being has mainly …