User profiles for Gregory E Crawford
![]() | Gregory CrawfordDuke University Verified email at duke.edu Cited by 68318 |
[HTML][HTML] High-resolution mapping and characterization of open chromatin across the genome
Mapping DNase I hypersensitive (HS) sites is an accurate method of identifying the location
of genetic regulatory elements, including promoters, enhancers, silencers, insulators, and …
of genetic regulatory elements, including promoters, enhancers, silencers, insulators, and …
[HTML][HTML] The accessible chromatin landscape of the human genome
DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned
the discovery of all classes of cis-regulatory elements including enhancers, promoters, …
the discovery of all classes of cis-regulatory elements including enhancers, promoters, …
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
Eukaryotic gene transcription is accompanied by acetylation and methylation of nucleosomes
near promoters, but the locations and roles of histone modifications elsewhere in the …
near promoters, but the locations and roles of histone modifications elsewhere in the …
Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS)
GE Crawford, IE Holt, J Whittle, BD Webb, D Tai… - Genome …, 2006 - genome.cshlp.org
A major goal in genomics is to understand how genes are regulated in different tissues,
stages of development, diseases, and species. Mapping DNase I hypersensitive (HS) sites …
stages of development, diseases, and species. Mapping DNase I hypersensitive (HS) sites …
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
Histone modifications at human enhancers reflect global cell-type-specific gene expression
…, R Stewart, JA Thomson, GE Crawford… - Nature, 2009 - nature.com
The human body is composed of diverse cell types with distinct functions. Although it is
known that lineage specification depends on cell-specific gene expression, which in turn is …
known that lineage specification depends on cell-specific gene expression, which in turn is …
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
Technologies that enable targeted manipulation of epigenetic marks could be used to
precisely control cell phenotype or interrogate the relationship between the epigenome and …
precisely control cell phenotype or interrogate the relationship between the epigenome and …
DNase-chip: a high-resolution method to identify DNase I hypersensitive sites using tiled microarrays
Mapping DNase I hypersensitive sites is an accurate method of identifying the location of gene
regulatory elements, including promoters, enhancers, silencers and locus control regions. …
regulatory elements, including promoters, enhancers, silencers and locus control regions. …
RNA-guided gene activation by CRISPR-Cas9–based transcription factors
Technologies for engineering synthetic transcription factors have enabled many advances
in medical and scientific research. In contrast to existing methods based on engineering of …
in medical and scientific research. In contrast to existing methods based on engineering of …
Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
…, AM Kabadi, TE Reddy, GE Crawford… - Nature …, 2015 - nature.com
Epigenome editing with the CRISPR (clustered, regularly interspaced, short palindromic
repeats)-Cas9 platform is a promising technology for modulating gene expression to direct cell …
repeats)-Cas9 platform is a promising technology for modulating gene expression to direct cell …