User profiles for Hamdi Mbarek
![]() | Hamdi MbarekDepartment of Biological Psychology, VU University Amsterdam, The Netherlands Verified email at vu.nl Cited by 13163 |
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
…, RM Maier, W Maier, J Marchini, H Mbarek… - Nature …, 2018 - nature.com
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …
architecture or its genetic relationship with other disorders. To discover loci associated …
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …
[HTML][HTML] Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease
Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic
loci across a range of human diseases and traits. However, most biobanks are primarily …
loci across a range of human diseases and traits. However, most biobanks are primarily …
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
…, MC Matheson, RA Mathias, K Matsumoto, H Mbarek… - Nature …, 2018 - nature.com
We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …
and has been reproducibly associated with future cardio-metabolic health outcomes. In …
Genetic insights into biological mechanisms governing human ovarian ageing
…, B Marco, J Marten, NG Martin, H Mbarek… - Nature, 2021 - nature.com
Reproductive longevity is essential for fertility and influences healthy ageing in women 1 , 2
, but insights into its underlying biological mechanisms and treatments to preserve it are …
, but insights into its underlying biological mechanisms and treatments to preserve it are …
[HTML][HTML] A large-scale genome-wide association study meta-analysis of cannabis use disorder
…, L Ligthart, A Loukola, B Maher, H Mbarek… - The Lancet …, 2020 - thelancet.com
Background Variation in liability to cannabis use disorder has a strong genetic component (estimated
twin and family heritability about 50–70%) and is associated with negative …
twin and family heritability about 50–70%) and is associated with negative …
Genome-wide analysis identifies 12 loci influencing human reproductive behavior
The genetic architecture of human reproductive behavior—age at first birth (AFB) and number
of children ever born (NEB)—has a strong relationship with fitness, human development, …
of children ever born (NEB)—has a strong relationship with fitness, human development, …
The genetic architecture of depression in individuals of East Asian ancestry: a genome-wide association study
…, RM Maier, W Maier, J Marchini, H Mbarek… - JAMA …, 2021 - jamanetwork.com
Importance Most previous genome-wide association studies (GWAS) of depression have used
data from individuals of European descent. This limits the understanding of the underlying …
data from individuals of European descent. This limits the understanding of the underlying …