Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …

The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …

Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic
loci across a range of human diseases and traits. However, most biobanks are primarily …

We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …

Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …

Reproductive longevity is essential for fertility and influences healthy ageing in women 1 , 2
, but insights into its underlying biological mechanisms and treatments to preserve it are …

Background Variation in liability to cannabis use disorder has a strong genetic component (estimated
twin and family heritability about 50–70%) and is associated with negative …

The genetic architecture of human reproductive behavior—age at first birth (AFB) and number
of children ever born (NEB)—has a strong relationship with fitness, human development, …

Importance Most previous genome-wide association studies (GWAS) of depression have used
data from individuals of European descent. This limits the understanding of the underlying …