User profiles for Markus M Nöthen
![]() | Markus NöthenVerified email at uni-bonn.de Cited by 34676 |
Biological insights from 108 schizophrenia-associated genetic loci
…, JL Moran, PB Mortensen, BJ Mowry, MM Nöthen… - Nature, 2014 - nature.com
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …
alleles, including common alleles of small effect that might be detected by genome-wide …
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
…, R Guerreiro, TW Mühleisen, MM Nöthen… - Nature …, 2009 - nature.com
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD)
involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 …
involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 …
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
…, R Guerreiro, TW Mühleisen, MM Nöthen… - Nature …, 2011 - nature.com
We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …
Large recurrent microdeletions associated with schizophrenia
Reduced fecundity, associated with severe mental disorders 1 , places negative selection
pressure on risk alleles and may explain, in part, why common variants have not been found …
pressure on risk alleles and may explain, in part, why common variants have not been found …
Common variants conferring risk of schizophrenia
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …
Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
We conducted a genome-wide association study for nonsyndromic cleft lip with or without
cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an …
cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an …
Analysis of shared heritability in common disorders of the brain
…, K Morgan, MM Nöthen, JM Schott, M Rossor… - Science, 2018 - science.org
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …
Identification of loci associated with schizophrenia by genome-wide association and follow-up
…, PV Gejman, S Cichon, MM Nöthen, M Gill… - Nature …, 2008 - nature.com
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls)
and tested loci with P < 10 −5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 …
and tested loci with P < 10 −5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 …
Genetic associations with valvular calcification and aortic stenosis
…, MM Nöthen, LA Cupples, M Caslake… - … England Journal of …, 2013 - Mass Medical Soc
Background Limited information is available regarding genetic contributions to valvular
calcification, which is an important precursor of clinical valve disease. Methods We determined …
calcification, which is an important precursor of clinical valve disease. Methods We determined …