User profiles for Sara Mostafavi
![]() | Sara MostafaviUniversity of Washington Verified email at cs.washington.edu Cited by 36597 |
Obtaining genetics insights from deep learning via explainable artificial intelligence
Artificial intelligence (AI) models based on deep learning now represent the state of the art
for making functional predictions in genomics research. However, the underlying basis on …
for making functional predictions in genomics research. However, the underlying basis on …
The genetic landscape of a cell
A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene
pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles …
pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles …
The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function
…, F Kazi, CT Lopes, A Maitland, S Mostafavi… - Nucleic acids …, 2010 - academic.oup.com
GeneMANIA ( http://www.genemania.org ) is a flexible, user-friendly web interface for
generating hypotheses about gene function, analyzing gene lists and prioritizing genes for …
generating hypotheses about gene function, analyzing gene lists and prioritizing genes for …
[HTML][HTML] GeneMANIA: a real-time multiple association network integration algorithm for predicting gene function
Background: Most successful computational approaches for protein function prediction
integrate multiple genomics and proteomics data sources to make inferences about the function …
integrate multiple genomics and proteomics data sources to make inferences about the function …
Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals
Understanding the consequences of regulatory variation in the human genome remains a
major challenge, with important implications for understanding gene regulation and …
major challenge, with important implications for understanding gene regulation and …
Multiplexed droplet single-cell RNA-sequencing using natural genetic variation
…, L Byrnes, CM Lanata, RE Gate, S Mostafavi… - Nature …, 2018 - nature.com
Droplet single-cell RNA-sequencing (dscRNA-seq) has enabled rapid, massively parallel
profiling of transcriptomes. However, assessing differential expression across multiple …
profiling of transcriptomes. However, assessing differential expression across multiple …
[HTML][HTML] Parsing the interferon transcriptional network and its disease associations
S Mostafavi, H Yoshida, D Moodley, H LeBoité… - Cell, 2016 - cell.com
Type 1 interferon (IFN) is a key mediator of organismal responses to pathogens, eliciting
prototypical "interferon signature genes" that encode antiviral and inflammatory mediators. For a …
prototypical "interferon signature genes" that encode antiviral and inflammatory mediators. For a …
[HTML][HTML] The genotype-tissue expression (GTEx) project
Genome-wide association studies have identified thousands of loci for common diseases,
but, for the majority of these, the mechanisms underlying disease susceptibility remain …
but, for the majority of these, the mechanisms underlying disease susceptibility remain …
A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease
S Mostafavi, C Gaiteri, SE Sullivan, CC White… - Nature …, 2018 - nature.com
There is a need for new therapeutic targets with which to prevent Alzheimer’s disease (AD),
a major contributor to aging-related cognitive decline. Here we report the construction and …
a major contributor to aging-related cognitive decline. Here we report the construction and …
The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans
Understanding the functional consequences of genetic variation, and how it affects complex
human disease and quantitative traits, remains a critical challenge for biomedicine. We …
human disease and quantitative traits, remains a critical challenge for biomedicine. We …