Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is
associated with increased risk of depression, but only in individuals exposed to stressful …

Importance Most previous genome-wide association studies (GWAS) of depression have used
data from individuals of European descent. This limits the understanding of the underlying …

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts,
which occur far more frequently, are a major source of disability and social and economic …

Objective: More than 90% of people who attempt suicide have a psychiatric diagnosis;
however, twin and family studies suggest that the genetic etiology of suicide attempt is partially …

A phenome-wide association and Mendelian Randomisation study of polygenic risk for
depression in UK Biobank - Ethnographic studies in innovative learning contexts Topic …

Background The heterogeneity of genetic effects on major depressive disorder (MDD) may
be partly attributable to moderation of genetic effects by environment, such as exposure to …

Background Antidepressants are a first-line treatment for depression. However, only a third
of individuals experience remission after the first treatment. Common genetic variation, in part…

It is imperative to understand the specific and shared etiologies of major depression and
cardio‐metabolic disease, as both traits are frequently comorbid and each represents a major …

Background: Motor vehicle accident studies thus far have focused primarily on psychiatric
consequences and outcomes and medicolegal and treatment aspects, particularly of …