Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression
…, C Holzman, EO Johnson, M Kennedy, M Laucht… - Molecular …, 2018 - nature.com
The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is
associated with increased risk of depression, but only in individuals exposed to stressful …
associated with increased risk of depression, but only in individuals exposed to stressful …
The genetic architecture of depression in individuals of East Asian ancestry: a genome-wide association study
Importance Most previous genome-wide association studies (GWAS) of depression have used
data from individuals of European descent. This limits the understanding of the underlying …
data from individuals of European descent. This limits the understanding of the underlying …
[HTML][HTML] Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders, and known risk factors
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts,
which occur far more frequently, are a major source of disability and social and economic …
which occur far more frequently, are a major source of disability and social and economic …
GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores
Objective: More than 90% of people who attempt suicide have a psychiatric diagnosis;
however, twin and family studies suggest that the genetic etiology of suicide attempt is partially …
however, twin and family studies suggest that the genetic etiology of suicide attempt is partially …
Major depressive disorder working group of the psychiatric genomics consortium
A phenome-wide association and Mendelian Randomisation study of polygenic risk for
depression in UK Biobank - Ethnographic studies in innovative learning contexts Topic …
depression in UK Biobank - Ethnographic studies in innovative learning contexts Topic …
Does childhood trauma moderate polygenic risk for depression? A meta-analysis of 5765 subjects from the psychiatric genomics consortium
Background The heterogeneity of genetic effects on major depressive disorder (MDD) may
be partly attributable to moderation of genetic effects by environment, such as exposure to …
be partly attributable to moderation of genetic effects by environment, such as exposure to …
[HTML][HTML] Identifying the common genetic basis of antidepressant response
Background Antidepressants are a first-line treatment for depression. However, only a third
of individuals experience remission after the first treatment. Common genetic variation, in part…
of individuals experience remission after the first treatment. Common genetic variation, in part…
Genetic comorbidity between major depression and cardio‐metabolic traits, stratified by age at onset of major depression
…, K Hodgson, M Traylor, TM Air… - American Journal of …, 2020 - Wiley Online Library
It is imperative to understand the specific and shared etiologies of major depression and
cardio‐metabolic disease, as both traits are frequently comorbid and each represents a major …
cardio‐metabolic disease, as both traits are frequently comorbid and each represents a major …
Posttraumatic stress disorder and its impact on the economic and health costs of motor vehicle accidents in South Australia
TM Air, AC McFarlane, D Psychother - J Clin Psychiatry, 2003 - psychiatrist.com
Background: Motor vehicle accident studies thus far have focused primarily on psychiatric
consequences and outcomes and medicolegal and treatment aspects, particularly of …
consequences and outcomes and medicolegal and treatment aspects, particularly of …