Schizophrenia has a heritability of 60–80% 1 , much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …

Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide
association study of 41,917 bipolar disorder cases and 371,549 controls of European …

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …

Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology.
Understanding the genetic factors contributing to the shared and disorder-specific symptoms …

We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls
of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10 −7 ); of …

Genome-wide association study (GWAS) analyses, at sufficient sample sizes and power,
have successfully revealed biological insights for several complex traits. RICOPILI, an open-…

Background Mood disorders (including major depressive disorder and bipolar disorder)
affect 10% to 20% of the population. They range from brief, mild episodes to severe, …

Background The heterogeneity of genetic effects on major depressive disorder (MDD) may
be partly attributable to moderation of genetic effects by environment, such as exposure to …

Background Antidepressants are a first-line treatment for depression. However, only a third
of individuals experience remission after the first treatment. Common genetic variation, in part…