User profiles for Vassily Trubetskoy
![]() | Vassily TrubetskoyCharité Universitätsmedizin Berlin Verified email at charite.de Cited by 8319 |
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Schizophrenia has a heritability of 60–80% 1 , much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide
association study of 41,917 bipolar disorder cases and 371,549 controls of European …
association study of 41,917 bipolar disorder cases and 371,549 controls of European …
Genome-wide association study identifies 30 loci associated with bipolar disorder
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …
[HTML][HTML] Genomic dissection of bipolar disorder and schizophrenia, including 28 subphenotypes
…, A Di Florio, S Papiol, JL Kalman, V Trubetskoy… - Cell, 2018 - cell.com
Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology.
Understanding the genetic factors contributing to the shared and disorder-specific symptoms …
Understanding the genetic factors contributing to the shared and disorder-specific symptoms …
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls
of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10 −7 ); of …
of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10 −7 ); of …
RICOPILI: rapid imputation for COnsortias PIpeLIne
…, J Goldstein, G Panagiotaropoulou, V Trubetskoy… - …, 2020 - academic.oup.com
Genome-wide association study (GWAS) analyses, at sufficient sample sizes and power,
have successfully revealed biological insights for several complex traits. RICOPILI, an open-…
have successfully revealed biological insights for several complex traits. RICOPILI, an open-…
The genetics of the mood disorder spectrum: genome-wide association analyses of more than 185,000 cases and 439,000 controls
…, S Ripke, EA Stahl, S Steinberg, V Trubetskoy… - Biological …, 2020 - Elsevier
Background Mood disorders (including major depressive disorder and bipolar disorder)
affect 10% to 20% of the population. They range from brief, mild episodes to severe, …
affect 10% to 20% of the population. They range from brief, mild episodes to severe, …
Does childhood trauma moderate polygenic risk for depression? A meta-analysis of 5765 subjects from the psychiatric genomics consortium
…, M Traylor, J Treutlein, V Trubetskoy… - Biological …, 2018 - Elsevier
Background The heterogeneity of genetic effects on major depressive disorder (MDD) may
be partly attributable to moderation of genetic effects by environment, such as exposure to …
be partly attributable to moderation of genetic effects by environment, such as exposure to …
[HTML][HTML] Identifying the common genetic basis of antidepressant response
Background Antidepressants are a first-line treatment for depression. However, only a third
of individuals experience remission after the first treatment. Common genetic variation, in part…
of individuals experience remission after the first treatment. Common genetic variation, in part…