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Cochrane Database of Systematic Reviews

Homocysteine‐lowering interventions for preventing cardiovascular events

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Information

DOI:
https://doi.org/10.1002/14651858.CD006612.pub3Copy DOI
Database:
  1. Cochrane Database of Systematic Reviews
Version published:
  1. 31 January 2013see what's new
Type:
  1. Intervention
Stage:
  1. Review
Cochrane Editorial Group:
  1. Cochrane Heart Group

Copyright:
  1. Copyright © 2013 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Authors

  • Arturo J Martí‐Carvajal

    Correspondence to: Facultad de Ciencias de la Salud Eugenio Espejo, Universidad Tecnológica Equinoccial, Quito, Ecuador

    [email protected]

  • Ivan Solà

    Iberoamerican Cochrane Centre, Institute of Biomedical Research (IIB Sant Pau), Barcelona, Spain

  • Dimitrios Lathyris

    "George Gennimatas" General Hospital, Thessaloniki, Greece

  • Despoina‐Elvira Karakitsiou

    University of Ioannina Medical School, Ioannina, Greece

  • Daniel Simancas‐Racines

    Facultad de Ciencias de la Salud Eugenio Espejo, Universidad Tecnológica Equinoccial, Quito, Ecuador

Contributions of authors

Arturo Marti‐Carvajal took the lead on writing up the Cochrane review.
Ivan Solà identified trials, extracted data, edited the 'Summary of findings' table and drafted the Cochrane review.
Dimitris Lathyris extracted and checked the data and reviewed the Cochrane review.
Despoina‐Elvira Karakitsiou checked the data, drafted the Cochrane review.
Daniel Simancas‐Racines checked the data and the 'Risk of bias' table.

Sources of support

Internal sources

  • No sources of support supplied

External sources

  • Iberoamerican Cochrane Centre, Spain.

    Academic

  • Facultad de Ciencias de la Salud Eugenio Espejo, Universidad Tecnológica Equinoccial, Quito, Ecuador.

    Academic

  • Cochrane Heart Group, UK.

    Academic

Declarations of interest

Ivan Solà, Dimitrios Lathyris, Despoina‐Elvira Karakitsiou and Daniel Simancas‐Racines: none known.

In 2004 Arturo Martí‐Carvajal was employed by Eli Lilly to run a four‐hour workshop on 'how to critically appraise clinical trials on osteoporosis and how to teach this'. This activity was not related to his work with The Cochrane Collaboration or any Cochrane review.

In 2007 Arturo Martí‐Carvajal was employed by Merck to run a four‐hour workshop 'how to critically appraise clinical trials and how to teach this'. This activity was not related to his work with The Cochrane Collaboration or any Cochrane review.

Acknowledgements

We express our gratitude to Cochrane Heart Group and peer referees for the suggestions to enhance the quality of this review. In addition, we acknowledge Dr Temis Maria Felix for giving us permission to publish the Figure 1 from Brustolin 2010, to Carmen Verônica Abdala from BIREME/OPS/OMS for her help to develop the strategy of the search in LILACS. In addition, we want express our deep gratitude to Georgia Salanti for teaching us how to conduct the first version of this Cochrane review.

Version history

Published

Title

Stage

Authors

Version

2017 Aug 17

Homocysteine‐lowering interventions for preventing cardiovascular events

Review

Arturo J Martí-Carvajal, Ivan Solà, Dimitrios Lathyris, Mark Dayer

https://doi.org/10.1002/14651858.CD006612.pub5

2015 Jan 15

Homocysteine‐lowering interventions for preventing cardiovascular events

Review

Arturo J Martí‐Carvajal, Ivan Solà, Dimitrios Lathyris

https://doi.org/10.1002/14651858.CD006612.pub4

2013 Jan 31

Homocysteine‐lowering interventions for preventing cardiovascular events

Review

Arturo J Martí‐Carvajal, Ivan Solà, Dimitrios Lathyris, Despoina‐Elvira Karakitsiou, Daniel Simancas‐Racines

https://doi.org/10.1002/14651858.CD006612.pub3

2009 Oct 07

Homocysteine lowering interventions for preventing cardiovascular events

Review

Arturo J Martí‐Carvajal, Ivan Solà, Dimitrios Lathyris, Georgia Salanti

https://doi.org/10.1002/14651858.CD006612.pub2

2009 Jul 08

Homocysteine lowering interventions for preventing cardiovascular events

Protocol

Arturo J Martí‐Carvajal, Georgia Salanti, Ricardo Hidalgo, Agustín Ciapponi

https://doi.org/10.1002/14651858.CD006612

Differences between protocol and review

This update includes a trial sequential analysis.

In this previous version (Marti‐Carvajal 2009), we searched into Allied and Complementary Medicine ‐ AMED (accessed through Ovid), and the Cochrane Stroke Group Specialised Register. For this update, we did not search either database.

PICOs

Population
Intervention
Comparison
Outcome

The PICO model is widely used and taught in evidence-based health care as a strategy for formulating questions and search strategies and for characterizing clinical studies or meta-analyses. PICO stands for four different potential components of a clinical question: Patient, Population or Problem; Intervention; Comparison; Outcome.

See more on using PICO in the Cochrane Handbook.