Abstract
Exercise has been shown to have beneficial effects on brain functions in humans and animals. Exercise can improve memory and learning in age-related neurodegenerative diseases. In animal models, physical exercise regulates epigenetics, promotes synaptic plasticity and hippocampal neurogenesis, regulates the expression levels of neurotrophic factors, and improves cognitive function. Therefore, exercise is very important for brain rehabilitation and remodeling. The purpose of this review is to explore the mechanisms by which exercise exerts positive effects on brain function. This knowledge implies that physical exercise can be used as a non-drug therapy for neurological diseases.
Funding source: The grants from the Ministry of Education of China
Award Identifier / Grant number: IRT0935
Funding source: The National Key R&D Program of China
Award Identifier / Grant number: 2017YFA 0104200
Funding source: The Fundamental Research Funds for the Central Universities
Funding source: The grants from the Science and Technology Bureau of Sichuan Province
Award Identifier / Grant number: 2016TD0002
Funding source: The grant from the clinical discipline program (Neonatology) from the Ministry of Health of China
Award Identifier / Grant number: 1311200003303
Funding source: National Natural Science Foundation of China
Award Identifier / Grant number: 81630038
Award Identifier / Grant number: 81971433
Award Identifier / Grant number: 81971428
Award Identifier / Grant number: 81771634
Award Identifier / Grant number: 81842011
Award Identifier / Grant number: 81330016
Award Identifier / Grant number: 81801629
Funding source: Ministry of Education of the People’s Republic of China
Funding source: Ministry of Health of China
Award Identifier / Grant number: 1311200003303
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: Our work was supported by the National Science Foundation of China (81630038, 81971433, 81971428, 81771634, 81842011, 81330016, 81801629), the National Key R&D Program of China (2017YFA 0104200), the grants from the Ministry of Education of China (IRT0935), the grants from the Science and Technology Bureau of Sichuan Province (2016TD0002), the grant from the clinical discipline program (Neonatology) from the Ministry of Health of China (1311200003303), and the Fundamental Research Funds for the Central Universities.
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Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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