摘要
光动力疗法是治疗癌症可供选择的放射和化疗法。光动力疗法临床上用于治疗年龄相关性黄斑变性和多种类型的癌症。选择性的治疗通常是由于光的应用。另一种提高选择性的方法是合成能识别和选择性聚集在肿瘤组织靶向光敏剂或纳米粒子。本文对有关使用叶酸作为靶向单元从而提高光敏剂对叶酸受体的选择性的文献数据进行了总结综述。我们将讨论连接叶酸和光敏剂或纳米颗粒的治疗方法以及叶酸存在对物体的光物理性质和在体外和体内的对选择性和光毒性的影响。
关键词: 叶酸,纳米粒子,光动力疗法,光敏剂,单线态氧。
Current Medicinal Chemistry
Title:The Interest of Folic Acid in Targeted Photodynamic Therapy
Volume: 22 Issue: 27
Author(s): Aurelie Stallivieri, Francis Baros, Gulim Jetpisbayeva, Bauyrzhan Myrzakhmetov and Celine Frochot
Affiliation:
关键词: 叶酸,纳米粒子,光动力疗法,光敏剂,单线态氧。
摘要: Photodynamic therapy is an alternative to chemotherapy and radiotherapy for cancer treatment. PDT is clinically applied to treat age-related macular degeneration and several types of cancer. Most of the time, the selectivity of the treatment is brought about by the application of light. Another strategy to improve selectivity is to design and synthesize targeted photosensitizers or nanoparticles, which can identify and selectively accumulate within tumor tissues. This review presents our inventory of all the data concerning the use of folic acid as a promising targeting unit to improve the selectivity of photosensitizers to folic acid receptors. We will discuss the strategies that are developed to couple folic acid to photosensitizers or nanoparticles as well as the influence of the presence of folic acid on the objects' photophysical properties and their effects on selectivity and phototoxicity in vitro and in vivo.
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Cite this article as:
Aurelie Stallivieri, Francis Baros, Gulim Jetpisbayeva, Bauyrzhan Myrzakhmetov and Celine Frochot , The Interest of Folic Acid in Targeted Photodynamic Therapy, Current Medicinal Chemistry 2015; 22 (27) . https://dx.doi.org/10.2174/0929867322666150729113912
DOI https://dx.doi.org/10.2174/0929867322666150729113912 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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