sufinpyrazone [Ligand Id: 5826] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL832 (Anturan, Anturane, NSC-75925, Sulfinpyrazone, Sulphinpyrazone)
  • FPR1/Formyl peptide receptor 1 in Human [ChEMBL: CHEMBL3359] [GtoPdb: 222] [UniProtKB: P21462]
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  • ABCC5/Multidrug resistance-associated protein 5 in Human [ChEMBL: CHEMBL2046258] [GtoPdb: 783] [UniProtKB: O15440]
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  • Urate anion exchanger 1/Solute carrier family 22 member 12 in Human [ChEMBL: CHEMBL6120] [GtoPdb: 1031] [UniProtKB: Q96S37]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
FPR1/Formyl peptide receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3359] [GtoPdb: 222] [UniProtKB: P21462]
GtoPdb - - 5 pIC50 - - - J Biomol Screen (2005) 10: 374-82 [PMID:15964939]
ChEMBL Antagonist activity at FPR1 F 5 pIC50 10000 nM IC50 Bioorg Med Chem Lett (2011) 21: 2991-2997 [PMID:21486695]
ABCC5/Multidrug resistance-associated protein 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2046258] [GtoPdb: 783] [UniProtKB: O15440]
ChEMBL TP_TRANSPORTER: inhibition of PMEA efflux (PMEA: 1 uM) in MRP5-expressing MDCKII cells F 4 pIC50 <100000 nM IC50 Proc Natl Acad Sci U S A (2000) 97: 7476-7481 [PMID:10840050]
Nicotinate phosphoribosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523354] [UniProtKB: Q6XQN6]
ChEMBL Inhibition of NAPRT (unknown origin) B 9.3 pKi 0.5 nM Ki WO-2017162840-A1. Sensitization of cancer cells to nampt inhibitors by nicotinic acid phosphoribosyltransferase neutralization (2017)
Urate anion exchanger 1/Solute carrier family 22 member 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6120] [GtoPdb: 1031] [UniProtKB: Q96S37]
GtoPdb - - 4 pIC50 100000 nM IC50 Drug Metab Dispos (2007) 35: 981-6 [PMID:17325024]
ChEMBL Inhibition of human URAT1-mediated urate uptake in HEK293 cells B 4 pIC50 100000 nM IC50 Drug Metab Dispos (2007) 35: 981-986 [PMID:17325024]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]

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