Fig. 4. Schematic presentation of quercetin action on uncoupling protein 1 (UCP1) induction. Quercetin enhances UCP1 expression through AMPK/PPARγ activation and sympathetic stimulation, promoting white adipose tissue browning and brown adipose tissue activation. β3AR, β3-adrenergic receptor; PPARγ, peroxisome proliferator-activated receptor gamma; PGC1α, PPARγ coactivator 1-alpha; AMPK, AMP-activated protein kinase; PKA, cyclic AMP-dependent protein kinase.
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