This is a Validated Antibody Database (VAD) review about human TDP 43, based on 27 published articles (read how Labome selects the articles), using TDP 43 antibody in all methods. It is aimed to help Labome visitors find the most suited TDP 43 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
TDP 43 synonym: ALS10; TDP-43

Abnova
mouse monoclonal (2E2-D3)
  • immunocytochemistry; human; 1:500; loading ...; fig 3
Abnova TDP 43 antibody (Abnova, H00023435-M01) was used in immunocytochemistry on human samples at 1:500 (fig 3). Acta Neuropathol Commun (2020) ncbi
mouse monoclonal (2E2-D3)
  • western blot; mouse; loading ...; fig 4a
In order to investigate the involvement of HspBP1 in the neuronal susceptibility towards misfolded proteins, Abnova TDP 43 antibody (Abnova, H00023435-M01) was used in western blot on mouse samples (fig 4a). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (2E2-D3)
  • immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 3a
In order to examine the mutation spectrum of the TANK-Binding Kinase 1 gene and its associated phenotypic spectrum in patients with FTD, ALS or FTD plus ALS, Abnova TDP 43 antibody (Abnova, 2E2-D3) was used in immunohistochemistry - paraffin section on human samples at 1:500 (fig 3a). Hum Mutat (2017) ncbi
mouse monoclonal (2E2-D3)
  • immunohistochemistry; fruit fly ; 1:500; loading ...; fig 7g
Abnova TDP 43 antibody (ABNOVA, H00023435-M01) was used in immunohistochemistry on fruit fly samples at 1:500 (fig 7g). J Biol Chem (2016) ncbi
mouse monoclonal (2E2-D3)
  • immunohistochemistry - paraffin section; human; 1:500; loading ...
In order to detail the neuropathological features of the anti-IgLON5 syndrome in order to diagnose patients, Abnova TDP 43 antibody (Abnova, 2E2-D3) was used in immunohistochemistry - paraffin section on human samples at 1:500. Acta Neuropathol (2016) ncbi
mouse monoclonal (2E2-D3)
  • immunocytochemistry; human; fig 5
  • western blot; human; fig 2a
In order to determine the subcellular localization of TDP-43 in circulating lymphomonocytes and in the constituent cells of patients with various ALS-linked mutant genes, Abnova TDP 43 antibody (Abnova, H00023435-M01) was used in immunocytochemistry on human samples (fig 5) and in western blot on human samples (fig 2a). Neuropathol Appl Neurobiol (2017) ncbi
mouse monoclonal (2E2-D3)
  • western blot; mouse; loading ...; fig 3c
Abnova TDP 43 antibody (Abnova, H00023435-M01) was used in western blot on mouse samples (fig 3c). Nat Commun (2016) ncbi
mouse monoclonal (2E2-D3)
  • immunocytochemistry; human; 1:1000
  • western blot; human; 1:2000
Abnova TDP 43 antibody (Abnova, 2E2-D3) was used in immunocytochemistry on human samples at 1:1000 and in western blot on human samples at 1:2000. J Biol Chem (2014) ncbi
mouse monoclonal (2E2-D3)
  • immunohistochemistry - paraffin section; human; 1:100; fig 5
In order to investigate the role of repressor element 1-silencing transcription factor in neurodegeneration during ageing, Abnova TDP 43 antibody (Abnova, H00023435-M01) was used in immunohistochemistry - paraffin section on human samples at 1:100 (fig 5). Nature (2014) ncbi
mouse monoclonal (2E2-D3)
  • western blot; human; fig 1
Abnova TDP 43 antibody (Abnova , H00023435-M01) was used in western blot on human samples (fig 1). Biochim Biophys Acta (2014) ncbi
Abcam
domestic rabbit monoclonal (EPR5810)
  • immunohistochemistry; mouse; 1:500; loading ...; fig 1a
  • western blot; mouse; loading ...; fig 4f
Abcam TDP 43 antibody (Abcam, ab109535) was used in immunohistochemistry on mouse samples at 1:500 (fig 1a) and in western blot on mouse samples (fig 4f). Nat Commun (2020) ncbi
mouse monoclonal (2E2-D3)
  • western blot; roundworm ; fig 9d
Abcam TDP 43 antibody (Abcam, ab57105) was used in western blot on roundworm samples (fig 9d). Acta Neuropathol Commun (2019) ncbi
domestic rabbit monoclonal
  • western blot; mouse; 1:10,000; loading ...; fig s4g
Abcam TDP 43 antibody (Abcam, Ab133547) was used in western blot on mouse samples at 1:10,000 (fig s4g). Nat Commun (2018) ncbi
mouse monoclonal (2E2-D3)
  • immunohistochemistry; human; loading ...; fig 3a
In order to research the effects of two familial ALS proteins on DNA damage repair, Abcam TDP 43 antibody (Abcam, ab57105) was used in immunohistochemistry on human samples (fig 3a). Proc Natl Acad Sci U S A (2016) ncbi
mouse monoclonal (2E2-D3)
  • immunohistochemistry - frozen section; domestic rabbit; fig s1
In order to characterize the role of endolysosomes in skeletal muscle pathology observed in a model of Alzheimer's disease with a cholesterol-fed rabbit, Abcam TDP 43 antibody (Abcam, ab57105) was used in immunohistochemistry - frozen section on domestic rabbit samples (fig s1). Front Aging Neurosci (2016) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - free floating section; mouse; 1:200; loading ...; fig 4b
In order to study cytosolic localization of Fox proteins in motor neurons of G93A SOD1 mice, Abcam TDP 43 antibody (Abcam, ab41881) was used in immunohistochemistry - free floating section on mouse samples at 1:200 (fig 4b). Histochem Cell Biol (2016) ncbi
BioLegend
rat monoclonal (1D3/TDP-43)
  • western blot; mouse; loading ...; fig 3a
BioLegend TDP 43 antibody (BioLegend, 829901) was used in western blot on mouse samples (fig 3a). Cell Rep (2021) ncbi
rat monoclonal (1D3/TDP-43)
  • immunocytochemistry; human; 1:500; loading ...; fig 7e
  • western blot; human; 1:500; loading ...; fig s5a
BioLegend TDP 43 antibody (Biolegend, 829901) was used in immunocytochemistry on human samples at 1:500 (fig 7e) and in western blot on human samples at 1:500 (fig s5a). Neuron (2019) ncbi
R&D Systems
mouse monoclonal (671834)
  • western blot; mouse; 1:1000; loading ...; fig 5d
R&D Systems TDP 43 antibody (Bio techne, MAB7778) was used in western blot on mouse samples at 1:1000 (fig 5d). iScience (2021) ncbi
Novus Biologicals
domestic rabbit polyclonal
  • immunohistochemistry - frozen section; mouse; 1:100; fig 5a
Novus Biologicals TDP 43 antibody (Novus Biologicals, NB110-55376) was used in immunohistochemistry - frozen section on mouse samples at 1:100 (fig 5a). Dis Model Mech (2017) ncbi
Santa Cruz Biotechnology
mouse monoclonal (41-7.1)
  • western blot; human; fig 5b
In order to show that upregulation of HSPB8 attenuates TDP-43 fragment-mediated toxicity, Santa Cruz Biotechnology TDP 43 antibody (Santa Cruz, sc-100871) was used in western blot on human samples (fig 5b). Hum Mol Genet (2016) ncbi
Cell Signaling Technology
domestic rabbit polyclonal
  • immunocytochemistry; human; loading ...; fig 6d
Cell Signaling Technology TDP 43 antibody (Cell signaling, 3448) was used in immunocytochemistry on human samples (fig 6d). Ann Neurol (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 4
Cell Signaling Technology TDP 43 antibody (Cell Signaling, 3449S) was used in western blot on mouse samples (fig 4). EMBO J (2016) ncbi
domestic rabbit polyclonal
  • western blot; mouse; fig 1
Cell Signaling Technology TDP 43 antibody (Cell signaling, 3448) was used in western blot on mouse samples (fig 1). Sci Rep (2016) ncbi
MilliporeSigma
domestic rabbit polyclonal
  • immunohistochemistry; mouse; 1:1000; loading ...; fig s5c
  • western blot; mouse; 1:5000; loading ...; fig 3a
MilliporeSigma TDP 43 antibody (Sigma, T1580) was used in immunohistochemistry on mouse samples at 1:1000 (fig s5c) and in western blot on mouse samples at 1:5000 (fig 3a). Nature (2017) ncbi
domestic rabbit polyclonal
  • immunohistochemistry; human; 1:500; loading ...; fig s3b
In order to show that expression of human TDP-43 impairs small interfering RNA silencing, the major post-transcriptional mechanism of retrotransposable element control in somatic tissue, MilliporeSigma TDP 43 antibody (Sigma Aldrich, SAB4200223) was used in immunohistochemistry on human samples at 1:500 (fig s3b). PLoS Genet (2017) ncbi
domestic rabbit polyclonal
  • immunohistochemistry - frozen section; human; 1:50; fig 7
  • western blot; human; fig 3
  • immunocytochemistry; mouse; 1:50; fig 2
MilliporeSigma TDP 43 antibody (Sigma, T1580) was used in immunohistochemistry - frozen section on human samples at 1:50 (fig 7), in western blot on human samples (fig 3) and in immunocytochemistry on mouse samples at 1:50 (fig 2). J Neurosci Res (2016) ncbi
Articles Reviewed
  1. Devoy A, Price G, De Giorgio F, Bunton Stasyshyn R, Thompson D, Gasco S, et al. Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models. iScience. 2021;24:103463 pubmed publisher
  2. Wani A, Zhu J, ULRICH J, Eteleeb A, Sauerbeck A, Reitz S, et al. Neuronal VCP loss of function recapitulates FTLD-TDP pathology. Cell Rep. 2021;36:109399 pubmed publisher
  3. Watanabe R, Higashi S, Nonaka T, Kawakami I, Oshima K, Niizato K, et al. Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions. Acta Neuropathol Commun. 2020;8:176 pubmed publisher
  4. Zhao L, Ke H, Xu H, Wang G, Zhang H, Zou L, et al. TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh. Nat Commun. 2020;11:341 pubmed publisher
  5. Latimer C, Burke B, Liachko N, Currey H, Kilgore M, Gibbons L, et al. Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort. Acta Neuropathol Commun. 2019;7:9 pubmed publisher
  6. Gasset Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, et al. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron. 2019;102:339-357.e7 pubmed publisher
  7. Luisier R, Tyzack G, Hall C, Mitchell J, Devine H, Taha D, et al. Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS. Nat Commun. 2018;9:2010 pubmed publisher
  8. Zhao T, Hong Y, Yin P, Li S, Li X. Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins. Proc Natl Acad Sci U S A. 2017;114:E7803-E7811 pubmed publisher
  9. Becker L, Huang B, Bieri G, Ma R, Knowles D, Jafar Nejad P, et al. Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice. Nature. 2017;544:367-371 pubmed publisher
  10. Krug L, Chatterjee N, Borges Monroy R, Hearn S, Liao W, Morrill K, et al. Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS. PLoS Genet. 2017;13:e1006635 pubmed publisher
  11. Kobayashi M, Chandrasekhar A, Cheng C, Martinez J, Ng H, de La Hoz C, et al. Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22. Dis Model Mech. 2017;10:215-224 pubmed publisher
  12. van der Zee J, Gijselinck I, Van Mossevelde S, Perrone F, Dillen L, Heeman B, et al. TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. Hum Mutat. 2017;38:297-309 pubmed publisher
  13. Hill S, Mordes D, Cameron L, Neuberg D, Landini S, Eggan K, et al. Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage. Proc Natl Acad Sci U S A. 2016;113:E7701-E7709 pubmed
  14. Matsukawa K, Hashimoto T, Matsumoto T, Ihara R, Chihara T, Miura M, et al. Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43. J Biol Chem. 2016;291:23464-23476 pubmed
  15. Hu B, Arpag S, Zuchner S, Li J. A novel missense mutation of CMT2P alters transcription machinery. Ann Neurol. 2016;80:834-845 pubmed publisher
  16. Crippa V, Cicardi M, Ramesh N, Seguin S, Ganassi M, Bigi I, et al. The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity. Hum Mol Genet. 2016;25:3908-3924 pubmed publisher
  17. Chen X, Wagener J, Ghribi O, Geiger J. Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease. Front Aging Neurosci. 2016;8:129 pubmed publisher
  18. Gelpi E, Hoftberger R, Graus F, Ling H, Holton J, Dawson T, et al. Neuropathological criteria of anti-IgLON5-related tauopathy. Acta Neuropathol. 2016;132:531-43 pubmed publisher
  19. De Marco G, Lomartire A, Calvo A, Risso A, De Luca E, Mostert M, et al. Monocytes of patients with amyotrophic lateral sclerosis linked to gene mutations display altered TDP-43 subcellular distribution. Neuropathol Appl Neurobiol. 2017;43:133-153 pubmed publisher
  20. Sellier C, Campanari M, Julie Corbier C, Gaucherot A, Kolb Cheynel I, Oulad Abdelghani M, et al. Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death. EMBO J. 2016;35:1276-97 pubmed publisher
  21. Williams K, Topp S, Yang S, Smith B, Fifita J, Warraich S, et al. CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia. Nat Commun. 2016;7:11253 pubmed publisher
  22. Lin P, Folorunso O, Taglialatela G, Pierce A. Overexpression of heat shock factor 1 maintains TAR DNA binding protein 43 solubility via induction of inducible heat shock protein 70 in cultured cells. J Neurosci Res. 2016;94:671-82 pubmed publisher
  23. Kitamura A, Nakayama Y, Shibasaki A, Taki A, Yuno S, Takeda K, et al. Interaction of RNA with a C-terminal fragment of the amyotrophic lateral sclerosis-associated TDP43 reduces cytotoxicity. Sci Rep. 2016;6:19230 pubmed publisher
  24. Ma X, Turnbull P, Crapper E, Wang H, Drannik A, Jiang F, et al. Cytosolic localization of Fox proteins in motor neurons of G93A SOD1 mice. Histochem Cell Biol. 2016;145:545-59 pubmed publisher
  25. Hans F, Fiesel F, Strong J, J ckel S, Rasse T, Geisler S, et al. UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination. J Biol Chem. 2014;289:19164-79 pubmed publisher
  26. Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, et al. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014;507:448-54 pubmed publisher
  27. De Marco G, Lomartire A, Mandili G, Lupino E, Buccinnà B, Ramondetti C, et al. Reduced cellular Ca(2+) availability enhances TDP-43 cleavage by apoptotic caspases. Biochim Biophys Acta. 2014;1843:725-34 pubmed publisher
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