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Bioactive Ingredients in Plants Related to Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 25 September 2024 | Viewed by 3243

Special Issue Editors


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Guest Editor
1. Department of Biotechnology and Biosciences, University Milano-Bicocca, 20126 Milan, Italy
2. National Biodiversity Future Center (NBFC), 90133 Palermo, Italy
Interests: amino acid metabolism; metabolomics; cell cycle; signal transduction; aging; protein aggregation; ubiquitination; phosphorylation; nutrition; neurodegeneration

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Guest Editor
1. Department of Biotechnology and Biosciences, University Milano-Bicocca, 20126 Milan, Italy
2. National Biodiversity Future Center (NBFC), 90133 Palermo, Italy
Interests: metabolism; cancer; environmental carcinogenesis; cadmium; neurodegeneration; protein aggregation; food and nutrition

Special Issue Information

Dear Colleagues,

This Special Issue, entitled “Bioactive Ingredients in Plants Related to Human Health”, will explore the impact of natural products, which originate from plants, on human wellness.

Plants contain secondary metabolites that are very specific and represent a fascinating library of bioactive compounds with a broad activity in the context of human health.

As society strives to transition towards more sustainable development pathways, it is important to investigate the link between biodiversity, nutritional status and human well-being.

Nutrients, supplements and herbal bioactive compounds have shown promise as complementary tools in the treatment and prevention of chronic Non-Communicable Diseases (NCDs), such as obesity, type II diabetes, cancer, cardiovascular diseases and neurodegenerative diseases.

Consistent with the journal Nutrients, we welcome original research articles, reviews and commentaries, aiming at elucidating the role of nutrients, supplements and herbal compounds in counteracting pathogenetic factors inducing NCDs, with a special emphasis on disease prevention.

Dr. Paola Coccetti
Dr. Paola Fusi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sustainability
  • prevention
  • healthy nutrition
  • chemical characterization
  • plant-based diets
  • non-communicable diseases
  • metabolism
  • oxidative stress
  • molecular mechanisms

Published Papers (3 papers)

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Research

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11 pages, 606 KiB  
Article
Effects of Nasal Solution Incorporating Resveratrol and Carboxymethyl-Β-Glucan in Preschool Non-Atopic Children with Wheezing
by Cristiana Indolfi, Costanza Mignini, Francesco Valitutti, Ilaria Bizzarri, Giulio Dinardo, Angela Klain, Michele Miraglia del Giudice and Giuseppe Di Cara
Nutrients 2024, 16(14), 2197; https://doi.org/10.3390/nu16142197 - 10 Jul 2024
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Abstract
Upper respiratory tract infections (URTI) account for more than 80% of wheezing episodes in children with a high incidence of hospitalization in preschool age. Most children with symptoms of wheezing during an URTI are usually non-atopic. As the majority of wheezing episodes resulting [...] Read more.
Upper respiratory tract infections (URTI) account for more than 80% of wheezing episodes in children with a high incidence of hospitalization in preschool age. Most children with symptoms of wheezing during an URTI are usually non-atopic. As the majority of wheezing episodes resulting from URTI are attributed to viral triggers, several studies have suggested the potential anti-inflammatory and antiviral properties of resveratrol. This study aims to identify the effect of resveratrol for pediatric non-atopic patients with recurrent wheezing triggered by URTIs. We conducted a prospective single-blind study to assess the effectiveness of a short course of nasal solutions incorporating resveratrol and carboxymethyl-β-glucan, administered for 7 days at the onset of URTIs, compared to standard nasal lavage with 0.9% saline solution. A total of 19 patients entered the active group, 20 patients were assigned to the placebo group. The comparison of overall wheezing days (p < 0.001), mean wheezing days per month (p < 0.01), and wheezing episodes per patient (p < 0.001) in the two groups showed a significant reduction in the group receiving resveratrol compared with the placebo group, with less hospital access (p < 0.001) and oral corticosteroid administration (p < 0.01). Our findings seem to suggest that, in non-atopic children with recurrent wheezing secondary to URTIs, nasal resveratrol could be effective to prevent or reduce the occurrence of wheezing, when started from the onset of upper airway symptoms. Full article
(This article belongs to the Special Issue Bioactive Ingredients in Plants Related to Human Health)
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24 pages, 9472 KiB  
Article
Phyto-Photodynamic Therapy of Prostate Cancer Cells Mediated by Yemenite ‘Etrog’ Leave Extracts
by Efrat Hochma, Paul Ben Ishai, Michael A. Firer and Refael Minnes
Nutrients 2024, 16(12), 1820; https://doi.org/10.3390/nu16121820 - 10 Jun 2024
Viewed by 617
Abstract
Cancer therapy, from malignant tumor inhibition to cellular eradication treatment, remains a challenge, especially regarding reduced side effects and low energy consumption during treatment. Hence, phytochemicals as cytotoxic sensitizers or photosensitizers deserve special attention. The dark and photo-response of Yemenite ‘Etrog’ leaf extracts [...] Read more.
Cancer therapy, from malignant tumor inhibition to cellular eradication treatment, remains a challenge, especially regarding reduced side effects and low energy consumption during treatment. Hence, phytochemicals as cytotoxic sensitizers or photosensitizers deserve special attention. The dark and photo-response of Yemenite ‘Etrog’ leaf extracts applied to prostate PC3 cancer cells is reported here. An XTT cell viability assay along with light microscope observations revealed pronounced cytotoxic activity of the extract for long exposure times of 72 h upon concentrations of 175 μg/mL and 87.5 μg/mL, while phototoxic effect was obtained even at low concentration of 10.93 μg/mL and a short introduction period of 1.5 h. For the longest time incubation of 72 h and for the highest extract concentration of 175 μg/mL, relative cell survival decreased by up to 60% (below the IC50). In combined phyto-photodynamic therapy, a reduction of 63% compared to unirradiated controls was obtained. The concentration of extract in cells versus the accumulation time was inversely related to fluorescence emission intensity readings. Extracellular ROS production was also shown. Based on an ATR-FTIR analysis of the powdered leaves and their liquid ethanolic extract, biochemical fingerprints of both polar and non-polar phyto-constituents were identified, thereby suggesting their implementation as phyto-medicine and phyto-photomedicine. Full article
(This article belongs to the Special Issue Bioactive Ingredients in Plants Related to Human Health)
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Review

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29 pages, 1223 KiB  
Review
Exploiting Natural Niches with Neuroprotective Properties: A Comprehensive Review
by Hind Moukham, Alessia Lambiase, Giovanni Davide Barone, Farida Tripodi and Paola Coccetti
Nutrients 2024, 16(9), 1298; https://doi.org/10.3390/nu16091298 - 26 Apr 2024
Viewed by 1719
Abstract
Natural products from mushrooms, plants, microalgae, and cyanobacteria have been intensively explored and studied for their preventive or therapeutic potential. Among age-related pathologies, neurodegenerative diseases (such as Alzheimer’s and Parkinson’s diseases) represent a worldwide health and social problem. Since several pathological mechanisms are [...] Read more.
Natural products from mushrooms, plants, microalgae, and cyanobacteria have been intensively explored and studied for their preventive or therapeutic potential. Among age-related pathologies, neurodegenerative diseases (such as Alzheimer’s and Parkinson’s diseases) represent a worldwide health and social problem. Since several pathological mechanisms are associated with neurodegeneration, promising strategies against neurodegenerative diseases are aimed to target multiple processes. These approaches usually avoid premature cell death and the loss of function of damaged neurons. This review focuses attention on the preventive and therapeutic potential of several compounds derived from natural sources, which could be exploited for their neuroprotective effect. Curcumin, resveratrol, ergothioneine, and phycocyanin are presented as examples of successful approaches, with a special focus on possible strategies to improve their delivery to the brain. Full article
(This article belongs to the Special Issue Bioactive Ingredients in Plants Related to Human Health)
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