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Substantial and necessary research examining the violence perpetrated against Native women continues to flourish, while violence and masculinity studies focused on Native men draws little attention. Meanwhile the murder rate of Native men is three times higher than Native women, twice as high as white men, and occurs at the hands of police more often than any other U.S. racialized group per capita. Colonization divided ‘Christians’ (white) and ‘heathens’ (Native), with settler whites identifying Native men as wild and threatening. I suggest the construct of settler colonialism and the ‘toxic gendering’ of Native masculinity continues today and impacts Native men internally (psychologically) and externally (rationally), contributing to violence perpetrated against and by them. This paper is an interpretive analysis of “Scary Brown Man” and Reservation Blues as examined through the intersection of the toxic gendering bias intrinsic to settler colonialism. Alexie’s novel offers a depiction of ‘typical’ reservation life and the conflicting struggle to maintain a healthy Native identity, while Ross’s article brings real-life situations into the conversation, encouraging the entry of intersectional discourse around Native masculinity into the arena of gender/bias research as applied to settler colonial studies while questioning the role of identity politics within disciplines. Full article

Adipose tissue, a central player in energy balance, exhibits significant metabolic flexibility that is often compromised in obesity and type 2 diabetes (T2D). Mitochondrial dysfunction within adipocytes leads to inefficient lipid handling and increased oxidative stress, which together promote systemic metabolic disruptions central to obesity and its complications. This review explores the pivotal role that mitochondria play in altering the metabolic functions of the primary adipocyte types, white, brown, and beige, within the context of obesity and T2D. Specifically, in white adipocytes, these dysfunctions contribute to impaired lipid processing and an increased burden of oxidative stress, worsening metabolic disturbances. Conversely, compromised mitochondrial function undermines their thermogenic capabilities, reducing the capacity for optimal energy expenditure in brown adipocytes. Beige adipocytes uniquely combine the functional properties of white and brown adipocytes, maintaining morphological similarities to white adipocytes while possessing the capability to transform into mitochondria-rich, energy-burning cells under appropriate stimuli. Each type of adipocyte displays unique metabolic characteristics, governed by the mitochondrial dynamics specific to each cell type. These distinct mitochondrial metabolic phenotypes are regulated by specialized networks comprising transcription factors, co-activators, and enzymes, which together ensure the precise control of cellular energy processes. Strong evidence has shown impaired adipocyte mitochondrial metabolism and faulty upstream regulators in a causal relationship with obesity-induced T2D. Targeted interventions aimed at improving mitochondrial function in adipocytes offer a promising therapeutic avenue for enhancing systemic macronutrient oxidation, thereby potentially mitigating obesity. Advances in understanding mitochondrial function within adipocytes underscore a pivotal shift in approach to combating obesity and associated comorbidities. Reigniting the burning of calories in adipose tissues, and other important metabolic organs such as the muscle and liver, is crucial given the extensive role of adipose tissue in energy storage and release. Full article