Abstract
Interactions between the central nervous system and the immune system have been studied primarily in the context of pathology, popularizing the view that interplay between these two systems is inherently detrimental. However, recent experimental data have demonstrated productive neuroimmune interactions that occur under normal physiological conditions. In this Essay, we outline our current understanding of contemporary neuroimmunology, describe a working model of T cell function in support of learning and memory, and offer ideas regarding the selective advantages of immune-mediated effects on brain function.
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Acknowledgements
We thank S. Smith and N. Watson for editing the manuscript. We thank the members of the Kipnis laboratory for their valuable comments during multiple discussions of this work. N.C.D. is the recipient of a Hartwell Foundation postdoctoral fellowship. This work was primarily supported by a grant from the US National Institute on Aging, National Institutes of Health (award AG034113 to J.K.).
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Kipnis, J., Gadani, S. & Derecki, N. Pro-cognitive properties of T cells. Nat Rev Immunol 12, 663–669 (2012). https://doi.org/10.1038/nri3280
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DOI: https://doi.org/10.1038/nri3280
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