How long will we live? And how much of that time will comprise a healthy life? What is aging, and can we stop or even reverse the aging process? What is the connection between aging and disease? Can we predict the evolving trends in the aging of human populations and prepare our societies for what has been called the Silver Tsunami? These are some of the important questions that the broad field of aging research is trying to address and that together form one of the Grand Challenges of the twenty-first century. The mission of Nature Aging is to provide a unique multidisciplinary, unifying and highly visible publishing platform for the aging-research community. The journal is highly selective yet broad in its coverage, publishing research from across the entire spectrum of the field, ranging from the basic biology of aging to the impact of aging on society. The journal aims to foster interactions among different areas of this diverse field of research and to promote new and exciting ideas within and beyond the research community, to enable synergy and maximize scientific and societal impact. http://feeds.nature.com/nataging/rss/current Nature Publishing Group en © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Aging © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com

https://www.nature.com/uploads/product/nataging/rss.gif http://feeds.nature.com/nataging/rss/current https://www.nature.com/articles/s43587-024-00664-6 Nature Aging, Published online: 08 July 2024; doi:10.1038/s43587-024-00664-6A study demonstrates the efficacy of immune-checkpoint blockade in prolonging survival and boosting CD8+ T cell function in aged mice after pathogen exposure. These findings highlight how aging-related immune changes may lead to augmented CD8+ T cell responses to checkpoint blockade, which results in improved protection from infection. The findings also highlight the importance of understanding immune aging in future efforts to target immunotherapies to older adults.]]> Daniel ThieleNicole L. La Gruta doi:10.1038/s43587-024-00664-6 Nature Aging, Published online: 2024-07-08; | doi:10.1038/s43587-024-00664-6 2024-07-08 Nature Aging 10.1038/s43587-024-00664-6 https://www.nature.com/articles/s43587-024-00664-6 https://www.nature.com/articles/s43587-024-00673-5 Nature Aging, Published online: 08 July 2024; doi:10.1038/s43587-024-00673-5Pharmacological TERT activation attenuates phenotypes of natural aging]]> Hannah Walters doi:10.1038/s43587-024-00673-5 Nature Aging, Published online: 2024-07-08; | doi:10.1038/s43587-024-00673-5 2024-07-08 Nature Aging 10.1038/s43587-024-00673-5 https://www.nature.com/articles/s43587-024-00673-5 https://www.nature.com/articles/s43587-024-00665-5 Nature Aging, Published online: 02 July 2024; doi:10.1038/s43587-024-00665-5A deep learning model accurately predicts 1-year mortality for the entire Finnish population. Despite robust performance and potential as a digital marker of aging, fairness analyses reveal prediction disparities, so integration into public health should be approached cautiously.]]> doi:10.1038/s43587-024-00665-5 Nature Aging, Published online: 2024-07-02; | doi:10.1038/s43587-024-00665-5 2024-07-02 Nature Aging 10.1038/s43587-024-00665-5 https://www.nature.com/articles/s43587-024-00665-5 https://www.nature.com/articles/s43587-024-00663-7 Nature Aging, Published online: 01 July 2024; doi:10.1038/s43587-024-00663-7Botanical extracts offer a valuable resource for identifying therapies. Zumerle, Sarill et al. show that a standardized extract of Salvia haenkei extends lifespan and healthspan in naturally aged mice by modulating inflammation and cellular senescence, and identify the constituent component luteolin as a senomorphic that disrupts the p16–CDK6 interaction.]]> Sara ZumerleMiles SarillMiriam SaponaroManuel ColucciLiliana ContuEdoardo LazzariniRoberta SartoriCamilla PezziniAnna RinaldiAnna ScanuJacopo SgrignaniPatrizia LocatelliMarianna SabbadinAurora ValdataDaniela BrinaIsabella GiacominiBeatrice RizzoAlessandra PierantoniSaman SharifiSilvia BressanClaudia AltomareYulia GoshovskaChiara GiraudoRoberto LuisettoLuca IaccarinoCristina TorcasioSimone MosoleEmiliano PasquiniAndrea RinaldiLaura PellegriniGregorio PeronMatteo FassanStefano MasieroAndrea Maria GioriStefano Dall’AcquaJohan AuwerxPietro CippàAndrea CavalliMarco BolisMarco SandriLucio BarileMonica MontopoliAndrea Alimonti doi:10.1038/s43587-024-00663-7 Nature Aging, Published online: 2024-07-01; | doi:10.1038/s43587-024-00663-7 2024-07-01 Nature Aging 10.1038/s43587-024-00663-7 https://www.nature.com/articles/s43587-024-00663-7 https://www.nature.com/articles/s43587-024-00662-8 Nature Aging, Published online: 28 June 2024; doi:10.1038/s43587-024-00662-8Using machine learning techniques applied to multimodal UK Biobank data, Wen et al. characterize the genetic basis of the biological age gaps of individual organs, uncovering interorgan cross-talk and links between chronic diseases, lifestyle factors and biological age gaps.]]> Junhao WenYe Ella TianIoanna SkampardoniZhijian YangYuhan CuiFilippos AnagnostakisElizabeth MamourianBingxin ZhaoArthur W. TogaAndrew ZaleskyChristos Davatzikos doi:10.1038/s43587-024-00662-8 Nature Aging, Published online: 2024-06-28; | doi:10.1038/s43587-024-00662-8 2024-06-28 Nature Aging 10.1038/s43587-024-00662-8 https://www.nature.com/articles/s43587-024-00662-8 https://www.nature.com/articles/s43587-024-00666-4 Nature Aging, Published online: 28 June 2024; doi:10.1038/s43587-024-00666-4Using longitudinal data from the ELSA-Brasil study, Gonçalves et al. report that income is a barrier to how adherence to the sustainable planetary health diet is linked to slower cognitive decline.]]> Natalia Gomes GonçalvesLeandro Teixeira CacauNaomi Vidal FerreiraPaulo Andrade LotufoAlessandra Carvalho GoulartMaria Carmen VianaSandhi Maria BarretoIsabela Martins BensenorDirce Maria MarchioniClaudia Kimie Suemoto doi:10.1038/s43587-024-00666-4 Nature Aging, Published online: 2024-06-28; | doi:10.1038/s43587-024-00666-4 2024-06-28 Nature Aging 10.1038/s43587-024-00666-4 https://www.nature.com/articles/s43587-024-00666-4 https://www.nature.com/articles/s43587-024-00654-8 Nature Aging, Published online: 26 June 2024; doi:10.1038/s43587-024-00654-8Older age is associated with metabolic stress and increases the risk of degeneration of organs that maintain metabolic homeostasis, including the liver. We discovered that aging promotes ferroptosis in hepatocytes, that ferroptotic stress is generally increased in degenerating organs, and that reducing ferroptosis reverses aging-related metabolic dysfunction and liver damage.]]> doi:10.1038/s43587-024-00654-8 Nature Aging, Published online: 2024-06-26; | doi:10.1038/s43587-024-00654-8 2024-06-26 Nature Aging 10.1038/s43587-024-00654-8 https://www.nature.com/articles/s43587-024-00654-8 https://www.nature.com/articles/s43587-024-00644-w Nature Aging, Published online: 25 June 2024; doi:10.1038/s43587-024-00644-wAge-related immune dysfunction can compromise immune responses to infection and vaccine efficacy. Across two cohorts, Dallan et al. demonstrate that protective immunity against severe acute respiratory syndrome coronavirus is optimally maintained in older adults after primary adenoviral immunization (ChAdOx1-S) and subsequent mRNA vaccine boosting (BNT162b2 or mRNA-1273).]]> Beatrice DallanDavide ProiettoMartina De LaurentisEleonora GalleraniMara MartinoSara GhiselliniAmedeo ZurloStefano VolpatoBenedetta GovoniMichela BorghesiValentina AlbaneseVictor AppayStefano BonniniSian Llewellyn-LaceySalvatore PacificoLaura GrumiroMartina BrandoliniSimona SempriniVittorio SambriKristin LadellHelen M. ParryPaul A. H. MossDavid A. PriceElena BarbieriTatiana BernardiMichela BoniLinda Dall’OlioMartina De LaurentisCaterina FioriniMichele FioriniMaurizio GovoniMargherita NeriFabio PalmaFranco RomagnoniAntonella CaputoRiccardo GavioliFrancesco Nicoli doi:10.1038/s43587-024-00644-w Nature Aging, Published online: 2024-06-25; | doi:10.1038/s43587-024-00644-w 2024-06-25 Nature Aging 10.1038/s43587-024-00644-w https://www.nature.com/articles/s43587-024-00644-w -