2DYL


Conserved Protein Domain Family
PKc_MKK7
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cd06618: PKc_MKK7 
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Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK7 is a dual-specificity PK that phosphorylates and activates its downstream target, c-Jun N-terminal kinase (JNK), on specific threonine and tyrosine residues. Although MKK7 is capable of dual phosphorylation, it prefers to phosphorylate the threonine residue of JNK. Thus, optimal activation of JNK requires both MKK4 and MKK7. MKK7 is primarily activated by cytokines. MKK7 is essential for liver formation during embryogenesis. It plays roles in G2/M cell cycle arrest and cell growth. In addition, it is involved in the control of programmed cell death, which is crucial in oncogenesis, cancer chemoresistance, and antagonism to TNFalpha-induced killing, through its inhibition by Gadd45beta and the subsequent suppression of the JNK cascade. The MKK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Links
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Statistics
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PSSM-Id: 270791
Aligned: 9 rows
Threshold Bit Score: 486.881
Created: 4-Apr-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 32 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1                                 #####   #             # #                               
2DYL_A         11 GYLTIGGQRYQ.[3].NDLENLGEMGSGTCGQVWKMRF.[4].HVIAVKQMRRS.[3].EENKRILMDLDVVLKS.[2]. 82   human
Q23977        181 GKLNINGRQYP.[3].NDLKHLGDLGNGTSGNVVKMMH.[4].TIIAVKQMRRT.[3].EENKRILMDLDVVLKS.[2]. 252  fruit fly
AAH68887      101 GYLGIDGQKYP.[3].NDLENLGEIGSGTCGQVWKMRF.[4].HVIAVKQMRRS.[3].EENKRILMDLDVVLKS.[2]. 172  African clawed frog
BAE06548      114 GKLRIDSMIYE.[3].EQFENLGQIGSGTCGQVYKMRY.[3].HVMAVKQMHRS.[3].EENKRILMDLDIVQKS.[2]. 184  Ciona intestinalis
AAA79746       56 GYLTLQGNRRK.[3].KELQFVEDIGHGSCGTVTKCRY.[2].VIMAVKTMPRT.[3].YEMSRILMDLDVICLS.[2]. 125  nematode
AAA81711      106 GTLEIDGEKQV.[3].NEIHIISLLGSGSCGVVESATV.[2].KLMAVKTMYKN.[3].ENLKRILRDVRIMSMC.[1]. 174  nematode
XP_001635447   27 GILKLGDKKYD.[3].DDLEMSGEIGYGTCGQVCKMKH.[4].QVLAVKRMARS.[3].EEQKRILMDLEVVMKS.[2]. 98   starlet sea anemone
EDP34102      126 GRITIMKTMYE.[3].ESLKRIGELGSGTCGVVYKARF.[4].TIMAVKQMVMT.[3].EENKRVLMDLEVVLXS.[2]. 197  agent of lymphatic...
XP_002109884   13 GLLTIDGKKYK.[3].DDLQVMGQIGSGTCGTVYAMEH.[4].SVIAVKKIPRI.[3].EEKKRVLMDLQVVMKS.[2]. 84   Trichoplax adhaerens


Feature 1             #                  ####     ##  #                                         # 
2DYL_A         83 CPYIVQCFGTFIT.[2].DVFIAMELM.[1].TCAEKLKKR.[5].PERILGKMTVAIVKALYYLKE.[1].HGVIHRDV 151  human
Q23977        253 CKYIVKCLGCFVR.[2].DVWICMELM.[1].MCFDKLLKL.[5].PEQILGKVTVATVNALSYLKD.[1].HGVIHRDV 321  fruit fly
AAH68887      173 CPYIVQCYGTFIT.[2].DVFIAMELM.[1].TCAEKLKKR.[5].PEAILGKMTVAIVNALYYLKE.[1].HGVIHRDV 241  African clawed frog
BAE06548      185 CPNIVKCYGTFVT.[2].NVWICMELM.[1].TCFDKLKKK.[5].PENILGKLTVSVVKALHYLKE.[1].HGVIHRDV 253  Ciona intestinalis
AAA79746      126 CPYIVRCFGYFIT.[2].DVRVCMECM.[1].TCLDRLLIR.[5].PERIIGKLSVSIIKALHYLKT.[1].HQIMHRDV 194  nematode
AAA81711      175 SPFIVTSYGYFMF.[2].SVKICMQIM.[1].ACCEKLLRR.[9].PEFVAGHIVYSAISALDYLKE.[1].HSIIHRDI 247  nematode
XP_001635447   99 CPYIVTCMGALIS.[2].DVFICMELM.[1].TCLDKLLKR.[5].PEHILGKMAVAIVKALHYLKE.[1].HGVMHRDV 167  starlet sea anemone
EDP34102      198 CPHIVRCYGCFIT.[2].EVLICMELM.[1].TCLDKLSKR.[5].PEDILGKMAVSIIKALDYLKV.[1].QNIIHRDV 266  agent of lymphatic...
XP_002109884   85 CPYIVKCFGLLIA.[2].DILICMEKM.[1].TCLCKLLTR.[5].PEDILGKITVAVVKALHYLKQ.[1].HGVIHRDV 153  Trichoplax adhaerens


Feature 1         #### #            ##  #            #### #                              #        
2DYL_A        152 KPSNILLD.[2].GQIKLCDFGISGRLVDDKAKDRSAGCAAYMAPERIDP.[6].DYDIRADVWSLGISLVELA.[1].G 225  human
Q23977        322 KPSNILID.[2].GNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDP.[3].KYDIRADVWSLGITLVELA.[1].A 392  fruit fly
AAH68887      242 KPSNILLD.[2].GQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDP.[6].DYDIRADVWSLGISLVELA.[1].G 315  African clawed frog
BAE06548      254 KPSNILVN.[2].GDVKLCDFGISGRLVDSQAKTRAAGCTAYMAPERISP.[5].NYDIRADVWSLGISLVELA.[1].G 326  Ciona intestinalis
AAA79746      195 KPSNILLD.[2].GVIKLCDFGIAGRLIESRAHSKQAGCPLYMGPERLDP.[4].SYDIRSDVWSFGVTLVELA.[1].G 266  nematode
AAA81711      248 KPSNILFD.[2].GNVKLCDFGISGFMTDSMAHSKSAGCPPYMAPERLTI.[4].KYDVRSDVWSLGITVYQLV.[1].G 319  nematode
XP_001635447  168 KPSNMLLD.[2].GCVKLCDFSISGRLVDSKAKTKSAGCAAYMAPERIDP.[6].NYDVRADVWSLGISLVELA.[1].G 241  starlet sea anemone
EDP34102      267 KPSNILLD.[2].GTVKLCDFGIAGRLVDSMARTRTAGCSAYMSPERLEA.[2].EYDVRADVWSIGISLVELA.[1].G 336  agent of lymphatic...
XP_002109884  154 KPSNILLD.[2].GNVKLCDFGISGRLVDSKARTRGKGCAAYMSPERIDP.[5].TYDIRADVWSLGISLVELA.[1].G 226  Trichoplax adhaerens


Feature 1             #                                                                           
2DYL_A        226 QFPYK.[4].DFEVLTKVLQEEPPLLPGH.[2].FSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYET.[ 3].DVA 298  human
Q23977        393 RSPYE.[4].DFEVLTKVLDSEPPCLPYG.[4].FSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYES.[ 3].DVP 467  fruit fly
AAH68887      316 QFPYK.[4].DFEVLTKVLQEEPPVLPHN.[2].FTLLFQSFVKDCLTKDHRKRPKYNKLMEHPFLRRYET.[ 3].EVA 388  African clawed frog
BAE06548      327 VFPYH.[4].DFEMLTKILEEAPPELPND.[2].FSIGFKRFVSFCCTKDYRYRPKYRDLLEHEFVRRHEH.[ 3].DIP 399  Ciona intestinalis
AAA79746      267 QYPYA.[2].EFDMMSKILNDEPPRLDPA.[1].FSPDFCQLVESCLQRDPTMRPNYDMLLQHPFVVHHEK.[ 3].DVE 336  nematode
AAA81711      320 LYPFP.[4].EFTTLTIIANLNLPSPSLR.[6].FSPLFIEFLDLCLRKDVRERPEYRQLMKHDFYLDYDP.[16].QVA 409  nematode
XP_001635447  242 EFPYR.[4].EFEVLTRVMGEDPPSLPGS.[2].FSHDFSSFVDECLTKDFHYRPKYNKLLVHPFITSYDS.[ 3].DVA 314  starlet sea anemone
EDP34102      337 EYPYR.[4].EFEVLSRIVSDPAPVLNPE.[2].FSPMFCDFLRLCLTKNYQFRPKYKELLQHEWVIHYET.[ 3].DVA 409  agent of lymphatic...
XP_002109884  227 KFPYD.[4].EFQVLTRILQDDPPKLPSN.[2].FSQEFCSFVEKCLIKDHDRRPKYAELLQHKFIQIYET.[ 3].DVA 299  Trichoplax adhaerens


Feature 1                  
2DYL_A        299 SWFKDVMAK 307  human
Q23977        468 NWFQSIKDN 476  fruit fly
AAH68887      389 SWFQDIMAR 397  African clawed frog
BAE06548      400 AWLRKVLIT 408  Ciona intestinalis
AAA79746      337 EWFADVMGE 345  nematode
AAA81711      410 DWFVDVIRL 418  nematode
XP_001635447  315 GWLKESLAS 323  starlet sea anemone
EDP34102      410 GWYQRIVQS 418  agent of lymphatic filariasis
XP_002109884  300 SWFNQLIEE 308  Trichoplax adhaerens

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