1QMZ,2IW8,1W98,1H27,2JGZ,1JST,1PW2,3QHR


Conserved Protein Domain Family
STKc_CDK1_CdkB_like
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cd07835: STKc_CDK1_CdkB_like 
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Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of Plant B-type Cyclin-Dependent protein Kinase
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK, CDK2, and CDK3. CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression while the CDK1/cyclin B complex is critical for G2 to M phase transition. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. Studies in knockout mice revealed that CDK1 can compensate for the loss of the cdk2 gene as it can also bind cyclin E and drive G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. The plant-specific B-type CDKs are expressed from the late S to the M phase of the cell cycle. They are characterized by the cyclin binding motif PPT[A/T]LRE. They play a role in controlling mitosis and integrating developmental pathways, such as stomata and leaf development. CdkB has been shown to associate with both cyclin B, which controls G2/M transition, and cyclin D, which acts as a mediator in linking extracellular signals to the cell cycle. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Links
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Statistics
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PSSM-Id: 270829
Aligned: 26 rows
Threshold Bit Score: 530.71
Created: 24-Jul-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1              ####    #               # #                  #             #              
1QMZ_A         5 FQKVEKIGEGTYGVVYKARNK.[2].GEVVALKKIRLD.[3].EGVPSTAIREISLLKELNHPNIVKLLDVIH.[3].KL 77  human
NP_524420      8 FQRAEKIGEGTYGIVYKARSN.[2].GQDVALKKIRLE.[3].EGVPSTAIREISLLKNLKHPNVVQLFDVVI.[3].NL 80  fruit fly
P23111         4 YEKVEKIGEGTYGVVYKALDK.[2].NETIALKKIRLE.[3].EGVPSTAIREISLLKEMNHGNIVRLHDVVH.[3].RI 76  Zea mays
P34112        10 YQKLEKLGEGTYGKVYKAKEK.[2].GRMVALKKIRLE.[1].DGVPSTALREISLLKEVPHPNVVSLFDVLH.[3].RL 80  Dictyostelium discoi...
AAD34354      10 YQKLEKIGEGTYGLVYKARDN.[2].GDIVALKKIRMD.[3].EGVPSTAIREISLLKEVQHPNIVPLKDVVY.[3].RL 82  Paramecium tetraurelia
XP_002116535   4 FHKLEKIGEGTYGKVYKACNK.[2].GQTVALKKIRLD.[3].EGVPSTTLREISILRSLNHSFVVRLYDVVH.[3].CL 76  Trichoplax adhaerens
P00546         8 YKRLEKVGEGTYGVVYKALDL.[5].QRVVALKKIRLE.[3].EGVPSTAIREISLLKELKDDNIVRLYDIVH.[4].KL 84  baker's yeast
CAA54746       4 YEKVEKIGEGTYGVVYKARDR.[2].NETIALKKIRLE.[3].EGVPSTAIREISLLKEMQHGNIVRLQDVVH.[3].RL 76  Norway spruce
AAV68595       4 YEKVAKIGEGTYGVVYKAKSL.[2].DAMVALKRIRLD.[3].EGVPSTAIREISLLKELRHENVVSLLEVIH.[3].KL 76  Ostreococcus tauri
ACO61089      26 FEKVEKIGEGTYGVVYKARDR.[2].DSVVALKRIRLD.[3].EGVPSTAIREISLLKELKHENIVSLMDVIH.[3].KL 98  Micromonas sp. RCC299


Feature 1           ####  # ##                                     # # ## #             #  #     
1QMZ_A        78 YLVFEFLHQDLKKFMDA.[5].IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN.[2].GAIKLADFGLARAFG 154 human
NP_524420     81 YMIFEYLNMDLKKLMDK.[4].FTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQNLLVD.[2].GKIKLADFGLARAFN 156 fruit fly
P23111        77 YLVFEYLDLDLKKFMDS.[5].KNPTLIKSYLYQILHGVAYCHSHRVLHRDLKPQNLLID.[3].NALKLADFGLARAFG 154 Zea mays
P34112        81 YLVFEYLDQDLKKYMDS.[3].LCPQLIKSYLYQLLKGLAYSHGHRILHRDLKPQNLLID.[2].GALKLADFGLARAVS 155 Dictyostelium discoi...
AAD34354      83 YLIFDFVDLDLKKYMES.[3].LDRMQVKKFINQMIQALNYCHQNRVIHRDLKPQNILVD.[3].QNTQIADFGLARAFG 158 Paramecium tetraurelia
XP_002116535  77 YLVFEYLDHDLKHYLDH.[3].IPPALLKSYLYQMLRAISYCHSRRVLHRDLKPQNLLID.[2].GTLKLADFGLARIFG 151 Trichoplax adhaerens
P00546        85 YLVFEFLDLDLKRYMEG.[6].LGADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLIN.[2].GNLKLGDFGLARAFG 162 baker's yeast
CAA54746      77 YLVFEYLDLDLKKHMDS.[5].KDPRLIKTFLYQILRGIAYCHSHRVLHRDLKPQNLLID.[3].NALKLADFGLARAFG 154 Norway spruce
AAV68595      77 YLVFEYLDLDLKKHMDS.[5].NDRMVIKGYVYQICAGIAFCHSHRVLHRDLKPQNLLID.[3].NVLKLADFGLARAFG 154 Ostreococcus tauri
ACO61089      99 YLVFEFLDVDLKKHLDT.[5].NDRRVIKGYLYQMCAGIAYCHSHRVLHRDLKPQNLLVD.[3].NVLKLADFGLARAFG 176 Micromonas sp. RCC299


Feature 1              # #### #                                           ##                     
1QMZ_A       155 VPVRTYXHEVVTLWYRAPEILLG.[3].YSTAVDIWSLGCIFAEMVT.[1].RALFPGDSEIDQLFRIFRTLGTPDEVVW 228 human
NP_524420    157 VPMRAYTHEVVTLWYRAPEILLG.[3].YSTGVDIWSLGCIFSEMIM.[1].RSLFPGDSEIDQLYRIFRTLSTPDETNW 230 fruit fly
P23111       155 IPVRTFTHEVVTLWYRAPEILLG.[3].YSTPVDVWSVGCIFAEMVN.[1].KPLFPGDSEIDELFKIFRILGTPNEQSW 228 Zea mays
P34112       156 IPVRVYTHEIVTLWYRAPEVLLG.[3].YSVPVDMWSVGCIFGEMLN.[1].KPLFSGDCEIDQIFRIFRVLGTPDDSIW 229 Dictyostelium discoi...
AAD34354     159 LPLKTYTHEVITLWYRAPEILLG.[3].YSTPVDIWSLGCIFAEMAQ.[1].RPLFCGDSEIDQLFKIFKIMGTPKESTW 232 Paramecium tetraurelia
XP_002116535 152 LPVRQYTHEVITLWYRAPEILLG.[3].YSTPVDIWSIGCIFVEMIN.[1].RPLFAGDSEIDQLFRVFRTLGTPDEITW 225 Trichoplax adhaerens
P00546       163 VPLRAYTHEIVTLWYRAPEVLLG.[3].YSTGVDTWSIGCIFAEMCN.[1].KPIFSGDSEIDQIFKIFRVLGTPNEAIW 236 baker's yeast
CAA54746     155 IPVRTFTHEVVTLWYRAPEILLG.[3].YSTPVDVWSVGCIFAEMVN.[1].RPLFPGDSEIDELFKIFRVLGTPNEETW 228 Norway spruce
AAV68595     155 IPVRAYTHEVVTLWYRAPEILLG.[3].YSTPVDVWSIGCIMAEMVN.[1].APLFPGDSEIDELFKIFKTLGTPGETLW 228 Ostreococcus tauri
ACO61089     177 IPLRAYTHEVVTLWYRSPEILLG.[3].YSTPVDVWSIGCIFAEMIN.[1].APLFPGDSEIDELFRIFRVLGTPDDGAW 250 Micromonas sp. RCC299


Feature 1                                                                             
1QMZ_A       229 PGV.[3].PDYKPSFPKWARQDF     SKVVPP.[2].EDGRSLLSQMLHYDPNKRISAKAALAHPFF 287 human
NP_524420    231 PGV.[3].PDFKTKFPRWEGTNM     PQPITE     HEAHELIMSMLCYDPNLRISAKDALQHAYF 287 fruit fly
P23111       229 PGV.[3].PDFKTAFPRWQAQDL     ATVVPN.[2].PAGLDLLSKMLRYEPSKRITARQALEHEYF 287 Zea mays
P34112       230 PGV.[3].PEYVSTFPNWPGQPY     NKIFPR.[2].PLALDLIAKMLQYEPSKRISAKEALLHPYF 288 Dictyostelium discoideum
AAD34354     233 PGV.[3].PDFKSTFPRWPTPTN.[5].GKDITN.[2].PLGLDLLSKMITYDPYARITAEEALKHAYF 296 Paramecium tetraurelia
XP_002116535 226 PGV.[3].SDYKSTFPKWPSRDL     NSVIYS.[2].EDCVDLIKQMLVYEPNGRISARLALQHPYF 284 Trichoplax adhaerens
P00546       237 PDI.[3].PDFKPSFPQWRRKDL     SQVVPS.[2].PRGIDLLDKLLAYDPINRISARRAAIHPYF 295 baker's yeast
CAA54746     229 PGV.[3].PDFKSAFPKWPAKDL     ATVVPG.[2].PAGIDLLSKMLCLEPSKRITARSALEHEYF 287 Norway spruce
AAV68595     229 PEA.[3].PDYQEGFPKWKAKPW     ESLCPA.[2].EAGVDLLRSLLQYSPEKRISAKYATQHRWF 287 Ostreococcus tauri
ACO61089     251 QGV.[3].PDYKTQFPQWRAKEW     KDICPS.[2].EAGLDLLEQMLQYAPHKRISARDACNHRFF 309 Micromonas sp. RCC299

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