5EAN,5EAX,5EAW


Conserved Protein Domain Family
DEXXQc_DNA2

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cd18041: DEXXQc_DNA2 
Click on image for an interactive view with Cn3D
DEXXQ-box helicase domain of DNA2
DNA2 (DNA Replication Helicase/Nuclease 2) possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5-3 helicase, and endonuclease activities, and is involved in DNA replication and DNA repair in the nucleus and mitochondrion. It is involved in Okazaki fragment processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. It is also involved in 5-end resection of DNA during double-strand break (DSB) repair; it is recruited by BLM and mediates the cleavage of 5-ssDNA, while the 3-ssDNA cleavage is prevented by the presence of RPA. DNA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Statistics
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PSSM-Id: 350799
Aligned: 27 rows
Threshold Bit Score: 254.853
Created: 20-Jul-2011
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1         ###  #                          ####                                   #        
5EAN_A        629 GLNKPQRQAMKRVLL.[1].KDYTLIVGMPGTGKTTTICALVRIL.[5].SVLLTSYTH.[1].AVDNILLKL.[ 6].F 700  house mouse
5EAX_A        626 GLNKPQRQAMKRVLL.[1].KDYTLIVGMPGTGKTTTICALVRIL.[5].SVLLTSYTH.[1].AVDNILLKL.[ 6].F 697  house mouse
NP_001096933  635 NLNKVQQNAALRALT.[1].SSHLLIKGLPGTGKTQTLVALVRLL.[5].SVLITAQTH.[1].AVDNLIMRL.[ 6].M 706  fruit fly
CCA19997      772 ALNADQRIVVCSVLN.[1].LDYTLVLGMPGTGKTFLLAFIVRVL.[5].SVLITSYTH.[1].AVDHLLGKI.[10].M 847  Albugo laibachii Nc14
XP_002429631  722 KLNKEQQKAVVKSIL.[1].NEYLLIKGPPGTGKTETTASLVKVF.[5].TVLIAGHTH.[1].SVDNILLRL.[ 4].Y 791  human body louse
CBY18458      625 RLNVHQKKAIKLALE.[1].KSYSLIQGFPGSGKTSVIIELIRIL.[5].RVLITSHTH.[1].AVDNILARL.[11].T 701  Oikopleura dioica
ADY40891      662 RLNGEQAHAVVKSLV.[1].DDYVLIQGLPGSGKTSTIAVLVRCF.[5].SVLITSHTH.[1].AVDNLLLKL.[ 8].I 735  pig roundworm
EFV54264      649 GLNAEQKSAIVKTML.[1].DDYVLIKGFPGSGKSSAVIALIRTF.[5].SVLVCAYTN.[1].AVDHILLKL.[19].I 733  Trichinella spiralis
ABO98186       54 PLNDEQLLAVEKIVT.[1].EDYVLVQGFPGAGKTAMLVAAVKAL.[5].SVLITSHTH.[1].AIDNVFSRL.[ 7].F 126  Ostreococcus lucim...
XP_002996645  636 RLNENQKAALYSALN.[1].ENYKIVHGMPGTGKSSVIVLLIKIL.[5].KVLLVCYTN.[1].AITNILSRL.[ 1].T 702  Nosema ceranae BRL01

Feature 1                                                                                         
5EAN_A        701 LRLG.[35].HPIVATTCMGINH.[5].KTFDFCIVDEASQISQP.[9].RRFVLVGDHQQLPPLV.[7].LGMSESLFK 815  house mouse
5EAX_A        698 LRLG.[35].HPIVATTCMGINH.[5].KTFDFCIVDEASQISQP.[9].RRFVLVGDHQQLPPLV.[7].LGMSESLFK 812  house mouse
NP_001096933  707 MRLG.[33].PSIVGVTCLGCGH.[5].RQFDYCIVDEATQVLQP.[9].SKFVLVGDPEQLPPIV.[7].RGADETLFQ 819  fruit fly
CCA19997      848 LRIG.[30].TKLIGITCLSIPH.[6].RQFDFCIVDEATQITEP.[9].KTFVLVGDPHQLPPLV.[7].KGLNVSLFQ 958  Albugo laibachii Nc14
XP_002429631  792 LRLG.[32].RKVIASTCLGLDS.[5].KKFDVCIVDESSQVLQS.[9].DKFILVGDEDQLPPIV.[7].SGMSESLFD 903  human body louse
CBY18458      702 IRIG.[33].ARLVAGTCMGVSR.[6].GPVDYAIVDEAGQVSEP.[9].SKFILVGDPCQLPPLI.[7].NGAQISLME 815  Oikopleura dioica
ADY40891      736 LRLG.[37].TPIVACTCLAVAT.[6].RRFSICLVDEASLVLES.[9].EKFVLVGDSSQLSPLV.[7].EGMSVSLFD 853  pig roundworm
EFV54264      734 LRLG.[34].TLLVGCTCTTATM.[6].RTFNLCIIDEATLATEA.[9].EKFVLVGDPLQLKPLV.[7].QGMDISLFS 848  Trichinella spiralis
ABO98186      127 MRIG.[33].AMVVGATCHAMGH.[5].KMFDVVLIDESGQITLP.[9].KTFVLVGDHHQLPPLV.[7].GGLGRSLLA 239  Ostreococcus lucim...
XP_002996645  703 IRSY.[21].VDLVASTCFGFRD.[5].RSFDYCIIDEGSQQHLL.[9].QKFVIFGDHLQLKPLS.[3].TDLNMSLFE 799  Nosema ceranae BRL01

Feature 1                        ##
5EAN_A        816 RLE.[5].VVQLTVQYR 832  house mouse
5EAX_A        813 RLE.[5].VVQLTVQYR 829  house mouse
NP_001096933  820 RLD.[4].TAVLSLQYR 835  fruit fly
CCA19997      959 RLS.[6].VRQLTIQYR 976  Albugo laibachii Nc14
XP_002429631  904 RLS.[4].VVKLKYQYR 919  human body louse
CBY18458      816 RLS.[6].LRQLQIQYR 833  Oikopleura dioica
ADY40891      854 RLK.[5].LITLRYQYR 870  pig roundworm
EFV54264      849 KLE.[6].VVTLKRQYR 866  Trichinella spiralis
ABO98186      240 MLC.[6].VTKLSSQYR 257  Ostreococcus lucimarinus CCE9901
XP_002996645  800 YLL.[3].HSELTIQYR 814  Nosema ceranae BRL01

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