Conserved Protein Domain Family
betaCoV_Nsp2_HKU9-like
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cd21518: betaCoV_Nsp2_HKU9-like 
betacoronavirus non-structural protein 2 (Nsp2) similar to bat coronavirus HKU9 Nsp2, and related proteins from betacoronaviruses in the D lineage
Coronavirus non-structural proteins (Nsps) are encoded in ORF1a and ORF1b. Post infection, the genomic RNA is released into the cytoplasm of the cell and translated into two long polyproteins (pp), pp1a and pp1ab, which are then autoproteolytically cleaved by two viral proteases Nsp3 and Nsp5 into smaller subunits. Nsp2 is one of these subunits. This subgroup includes Nsp2 from Rousettus bat coronavirus HKU9 and betacoronaviruses in the nobecovirus subgenus (D lineage). It belongs to a family which includes Severe acute respiratory syndrome coronavirus (SARS-CoV) Nsp2, and Murine hepatitis virus (MHV) Nsp2 (also known as p65). The function of Nsp2 remains unclear. SARS-CoV Nsp2, rather than playing a role in viral replication, may be involved in altering the host cell environment; deletion of Nsp2 from the SARS-CoV genome results in only a modest reduction in viral titers. It has been shown to interact with two host proteins, prohibitin 1 (PHB1) and PHB2, which have been implicated in cellular functions, including cell-cycle progression, cell migration, cellular differentiation, apoptosis, and mitochondrial biogenesis. MHV Nsp2/p65, different from SARS-CoV Nsp2, may play an important role in the viral life cycle.
Links
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Statistics
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PSSM-Id: 394869
Aligned: 10 rows
Threshold Bit Score: 966.539
Created: 8-Apr-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure of SARS-CoV-2 Nsp2 with bound zinc ion
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1                                                                                      
P0C6T6     176 DVYLSDQYGFDNNGILVEPVMKLLGVIKSDFTLEQLLAALGKYRTEDGYDLPDGYVKVAIKVGRKAVPVLKQSIFTVVGV 255  Rousettus bat coronav...
ABN10934   176 DVYLSDQYGFDNNGVLVKPVQDLLGDIRPDFTLEELTLCLSDYRTDDGYDLLGGYVKVAVKVVRKPVPVVKQTIFTVQGV 255  Bat coronavirus HKU9-4
ADM33557   176 NAYMSDQYGFDNNGNLVKPVLELLGGIKPDLTLEKLTLALSEYRNSDGYDLPGGFVRVAVSVIRKPVPVVKQTIFTVQGV 255  Bat coronavirus HKU9-5-1
ADM33581   176 NAYMSDQYGFDNNGVLVKPVQDLLGDIKPDLTLEKLTLALSDYRKDDGYDLPGGFVKIAVTVIRKPVAVVKQTIFTVQGV 255  Bat coronavirus HKU9-...
AVP25405   176 NVYMSDQYGFDNNGILVEPVKELLGDIKPDLTLEQLTLALSEYRQDEGYDLPGGFVKVAVKVIRKPVPVAKQTIFTVQGV 255  Rousettus bat coronav...
QDF43839   176 NVFLSDQYGFDNNGTLVEPVKELLGAIKSDFTLEQLLAALSAYSKDDGYDLPGGFVKIAVTVIRKPLPVVRQSIFTVQGV 255  Coronavirus BtRt-Beta...
AOG30811   176 NTFLTDQYGFDADGVLAAPIKEVLGDKGAGMSLVELTKFLGKYRTADGYELPSGIVKVAVKVVRKNLPVSKQSIFTVLGV 255  Rousettus bat coronav...
AWV67046   174 GVVYTDQYGFDADGVLVKPIMDLLGPIKSGYTLANLLDDLAPYKCDDGYELPTGTVCIAFDVVRKNVPVVKQNIFTVQGV 253  Bat coronavirus
AWV67062   185 GVVYTDQYGFDADGVLAKPIVDLLGPFKSGYTLANLLDDLAPHKCDDGYELPTGTVCIAFEVVRKDVPVVKQNIFTVQGV 264  Bat coronavirus
AWV67038   175 GVFYTDQYGFDADGVLVKPIMDLLGPLKSGYTLANLLDDLAPYKCDDGYELPTGTVCVAFEVVRKNVPAAKQNIFTVQGV 254  Bat coronavirus


Feature 1                                                                #  #                  
P0C6T6     256 TEQLVPGYYYPFST.[3].VEHTKPTRGGPVGKTVEAVMLSLYGTNNYNPATPVARLKCSYCDYYGWTPLKDI.[1].TV 329  Rousettus bat coronav...
ABN10934   256 IEQCVEGYYYPFPP.[3].VKHTKPRSDKPLGKTVDSIMLSLYGTSGYNPATPVVRLRCSHCDFYGWVPLKDM.[1].TV 329  Bat coronavirus HKU9-4
ADM33557   256 VEQHVEGFYYPYST.[3].VKHTKPRSDKPLGKTVESIMLSLYGTSGYSPATPVVRLRCSYCDFYGWVPPRDM.[1].TV 329  Bat coronavirus HKU9-5-1
ADM33581   256 VEQHVEGYYYPYAP.[3].VKQTKPAAGGPIGKTVEAIMLSLYGTSGYKPATPVARLKCSYCDHFGWTPLKDM.[1].TV 329  Bat coronavirus HKU9-...
AVP25405   256 VEQHVEGYYYPYSP.[3].VKHTKPRSDKPVGKTVDAIMLSLYGTRCYNPATPVVRLRCGYCDFYGWVPPRDM.[1].TV 329  Rousettus bat coronav...
QDF43839   256 IEHLVEGYYYPLTT.[3].VKHTKPRPNVPLSNTVESIMLSLYGTSGYSPATPVVRLNCNYCYFYGWVPLRDM.[1].SV 329  Coronavirus BtRt-Beta...
AOG30811   256 TERVVDGFYYPYST.[3].VSYTKPRAGATVGNTVQSVMLSVYGTEAYNPVTPVVRLRCSSCDFYGWVPVKDL.[1].CV 329  Rousettus bat coronav...
AWV67046   254 LNQLVPGIYYPYSS.[3].VVTTKPARDSPAAKTVSSIMLSLYGTSQYAPVTPVARIACTTCGFLGWLPLKDA.[1].TV 327  Bat coronavirus
AWV67062   265 LNQLVPGIYYPYSS.[3].VVTTKPARDSPAAKTVSSIMLSLYGTAQYAPVTPVARIACPTCGFLGWLPLKDA.[1].TV 338  Bat coronavirus
AWV67038   255 LNQLVPGIYYPYSS.[3].VVTTKPARDSPAAKTVSSIMLSLYGTAQYAPVTPVARIACPTCGFLGWLPLKDA.[1].TV 328  Bat coronavirus


Feature 1       # #                                                                          
P0C6T6     330 NCLCGAEF.[3].SSCVDAESAGVIKPGCVMLLDKSPGMRLIPGNRTYVSFGGAIWSPIGKVNGVTVWVPRAYSIVAG 405  Rousettus bat coronavir...
ABN10934   330 SCSCSAVH.[3].SSCIDAESAGAIKPGCVMLLDKSPGMRVIPGNRTYVAFGGAIWSPIGKVGDVTVWVPRAYSVIAG 405  Bat coronavirus HKU9-4
ADM33557   330 VCSCGAEF.[3].SACVDAESAGAIKPGCVMLLDRSPGMRLIPGNRIYVAFGGAIWSPIGTVNGVSVWVPRSYSVVAG 405  Bat coronavirus HKU9-5-1
ADM33581   330 VCLCGAEY.[3].SSCVDAESAGLIKPGCVMLLDKSPGMRVIPGNRTYVAFGGAIWSPIGKVNDVTVWVPRAYSIVAG 405  Bat coronavirus HKU9-10-2
AVP25405   330 LCSCGAEY.[3].SNCVDAESAGAIRPGCVMLLDKSPGMRVIPGNRTYVAFGGCIWSPIGSVNGVTVWVPRSYSVIAG 405  Rousettus bat coronavir...
QDF43839   330 VCSCKAEH.[3].SSCIDAESAGVVKPGCVLLLDKSPGMRIIPGNRTYVAFGGAIWSPIGVVNNVTVWVPRIYSDLTD 405  Coronavirus BtRt-BetaCo...
AOG30811   330 TCSCAAVH.[3].SSCIDAESAGLIKQGAVMLVDRSPSMRVVPGNRLYVAFGGAIWSPIGKVNGVQVWVPRAYSCVAG 405  Rousettus bat coronavirus
AWV67046   328 VCGCNATY.[3].STAVQAESSGFIRQGAVLCLEKGEAMRLVPGGRTYLAFGGAIWSPIGKDKDVTVWVPRTYSVLCN 403  Bat coronavirus
AWV67062   339 VCGCNATY.[3].STAVQAESSGFIRQGAVLCLEKGEAMRLVPGGRTYLAFGGAIWSPIGKDKDVTVWVPRTYSVLCN 414  Bat coronavirus
AWV67038   329 VCGCNATY.[3].STAVQAESSGFIRQGAVLCLEKGEAMRLIPGGRTYLAFGGAIWSPIGKDKDVTVWVPRTYSVLCN 404  Bat coronavirus


Feature 1                                                                                      
P0C6T6     406 .[1].HSGAVGSGDTVAINKELVEYLIEGIRVDADTL.[5].ATFIANLDCDTKAPVVHTVESLQGLCLANKI.[1].LG 477  Rousettus bat coronav...
ABN10934   406 .[1].HSGAVGSCDVTAMNKELMAFIIEGFKIDEDTL.[5].AAFIANIQCDEKSPVVHTVDSITKMCLDNKV.[1].LG 477  Bat coronavirus HKU9-4
ADM33557   406 .[1].HSGAVGSCDVTTMNKEIMAFIIEGFKIDEDTL.[5].ATFIANMQCDEKTPVVHTVETIVQLCLDNKV.[1].LG 477  Bat coronavirus HKU9-5-1
ADM33581   406 .[1].HSGAVGSGAVLTINREIMAYIVEGFKIDDETL.[5].ASFIANLECDAKTPTVHTVESLKDLCLANKI.[1].LG 477  Bat coronavirus HKU9-...
AVP25405   406 .[1].HSGAVGSCDVTIMNRELIAYIIEGFKIDEDTL.[5].AAFIANMQCDEKTPVVHTVDTITQLCLNNKV.[1].LG 477  Rousettus bat coronav...
QDF43839   406 .[1].HTGAVGTGNVKLLNSEIKAFLVEGFKIDEDTL.[5].VSFVANLQCDDKPIVYTVESVKQLCIDNNVT     VG 476  Coronavirus BtRt-Beta...
AOG30811   406 .[1].HSGAVGSGDVNTINKEIMSLIIDGVRIDDEVL.[5].GVLIANLEDPSAAPRVHTVDSLRQLCVDNNV.[1].LG 477  Rousettus bat coronav...
AWV67046   404 .[1].HSGVVGTGDVRAYNEELVGLLSEGFFIDEEAL     AKESVSCMIADALPEDHDAVTLNVDLVKQYL.[6].LG 475  Bat coronavirus
AWV67062   415 .[1].HSGVVGTGDVRAYNEELVSLLSEGFFIDEEAL     AKESVSCMIADALPEDHDAVTLNVDLVKQYL.[6].LG 486  Bat coronavirus
AWV67038   405 .[1].HSGVVGTGDVRAYNEELVSLLSEGFFIDEEAL     AKESVSCMIADALPEDHDAVTLNVDLVKQYL.[6].LG 476  Bat coronavirus


Feature 1                                                                                      
P0C6T6     478 DKPLPTDEFHPFIVGL.[1].YHVQRACWYGALASRTFEA.[1].RDFVRTEEERFAQFFGKVCAPI.[9].TGRVTLFS 553  Rousettus bat coronav...
ABN10934   478 EHPLPDDEFHPAIVGM.[1].YYTQRTCWYAALSSKTFAA.[1].RDYVRREEERLRVFCGKAFTPV.[9].SGRVTLVT 553  Bat coronavirus HKU9-4
ADM33557   478 NHPLPDDEFHPVIVGL.[1].YYTQRTLWYAALNSKTFAA.[1].RDYVCREEERLRAFCGRAFIPV.[9].TGKVTLTS 553  Bat coronavirus HKU9-5-1
ADM33581   478 DKPLPTDEFHPVVVGL.[1].FYAQRACWYGTLASTTFEA.[1].RTFVRAEEERLAHFCGSVCAPI.[9].QGRVTVLS 553  Bat coronavirus HKU9-...
AVP25405   478 DHPLPDDEFHPAIVGL.[1].YYTQRACWYAALSSKTFSA.[1].REYVRKEEERLRVFCGRAFSPV.[9].SGKVTLVS 553  Rousettus bat coronav...
QDF43839   477 VHPIPEDEFHPALLGP.[1].YYTQRIYWYAALASTTFTA.[1].RTFVRKEEEKIAQFSVKMYAAL.[9].RGVVSLFT 552  Coronavirus BtRt-Beta...
AOG30811   478 DTPLPKDEFHPGIVGL.[1].YHFYRACWYGVLTAKSFGA.[1].KELLQSEEVRLSHFCANIRRCL.[9].TGNVSLLS 553  Rousettus bat coronav...
AWV67046   476 QRPVPSDPYHPAIQGV.[1].YHVRRACTLAMRAGVAFGA.[1].KTSFYKEVDRILVKVNFDYWQQ.[1].TTVNIPLR 543  Bat coronavirus
AWV67062   487 QRPVPSDPYHPAIQGV.[1].YHVRRACTLAMRAGVAFDA.[1].KTSFYKEVGLILVKVNFDYWQQ.[1].ATVNIPLR 554  Bat coronavirus
AWV67038   477 QRPVPSDPYHPAIQGV.[1].YHVRRACTLAMRAGVAFDA.[1].KTSFYREVGRILVKVNFDYWQQ.[1].ATVNIPLR 544  Bat coronavirus


Feature 1                                                                                      
P0C6T6     554 AYQVLNTAIAKSKDAFGGVAA.[3].DMLKPILEWVLKKM.[2].AKGAW.[2].YAEGLLALFKAQFTVVKGKFQFLRA 625  Rousettus bat coronav...
ABN10934   554 AYQVLDTALTKTKDAFGGAAV.[3].DLLKPTLDWVLTKM.[2].AKGVW.[2].YAETILALFKAQFTFVKGKFVFARD 625  Bat coronavirus HKU9-4
ADM33557   554 AYHVLEAALTKTKDAFGGAAA.[3].DLLKPVMDWVLNKM.[2].AKGIW.[2].YAEAILALFRAQFTFIEGKFHFVRD 625  Bat coronavirus HKU9-5-1
ADM33581   554 AFHVLNIAISKTKEAFGGAKS.[3].DILKPALDWVLKKM.[2].AKGVW.[2].YAEAILALFKAQFTFVKGKFQFVRG 625  Bat coronavirus HKU9-...
AVP25405   554 AYHVLDTALTKTKDAFGGASS.[3].DILKPVLDWVLTKM.[2].VKGVW.[2].YAEAILALFKAQFTLVKGKFVFLCD 625  Rousettus bat coronav...
QDF43839   553 GYQILEAFVTKTQVLVSDTLA.[3].AILKPTLEWVLNKM.[2].VKNTW.[2].YAEALIALFKAQFTVVKGKFFFLKD 624  Coronavirus BtRt-Beta...
AOG30811   554 SSLVLKALAENLLDSVKNTPF.[3].DLVKPVLDWIVEKM.[2].ARDSV.[2].CAEAVLSLFNMQFTFAKGKFTFLKE 625  Rousettus bat coronav...
AWV67046   544 AFLVLDAMVSESAVAWGHWTS.[3].DFIAAFKPWLLNAF.[2].TTQAI.[2].TALAVTHFLQVKFTYINGEFSFVVA 615  Bat coronavirus
AWV67062   555 AFFVLDAMVSEGAIAWGHWTS.[3].DLLAAFKPWLLNVF.[2].TTQAI.[2].TALALTQFLQAKFTYVNGEFAFLVT 626  Bat coronavirus
AWV67038   545 AFFVLDAMVSEGAIAWGHWTS.[3].DLLAAFKPWLLNVF.[2].TTQAI.[2].TALALTQFLQVKFTYINGEFSFLVA 616  Bat coronavirus


Feature 1                                                                                      
P0C6T6     626 SLNSKCHSLCDLLTTIMSKLLTSVKWAGCKVDALYTGTYYYFSRKGVLTEVQLCA.[2].LGLLLTPKQQKMEVEVLDGD 702  Rousettus bat coronav...
ABN10934   626 ALNKSCGALRDLLSVVLSKLLTSARWAGCKVEALYTGTYHYFAKCGVLSETQVCA.[2].LGVLLTPRQQKMEVEVLEGT 702  Bat coronavirus HKU9-4
ADM33557   626 TLNSSCGALRDLLSALLSKLLTSARWAGCKVEAVYTGTYHYFAKFGVVSELQIRA.[2].LGVLLTPRQQKMEVEVLEGK 702  Bat coronavirus HKU9-5-1
ADM33581   626 ALNKTCGNLRDMLTVVVGKLLTSVKWAGCKVEALYTGTYYYFSQNGLLTEVQVCA.[2].LGLLLTPRQQKMEVEVLDGD 702  Bat coronavirus HKU9-...
AVP25405   626 ALNKSCGALRDLLTVVFGKLLTTAKWAGCKVEAMYTGSYHYFSKCGVLTEAQVCA.[2].LGVLLTPKQQKMEVEVLEGT 702  Rousettus bat coronav...
QDF43839   625 ALNKPCGALRDLLAVVLTKLLTTAKWAGCKVEALYVDGYYYFSNCGLLTETQVCA.[2].LGVLLTPKQQKMEVEVLQGA 701  Coronavirus BtRt-Beta...
AOG30811   626 KLNKSCVALRELLTVIVNKFATTVKWAGCKIDGFYNGDYHFFSAKGVLTEVQVCA.[2].LGAMLTPRQQRMEVEVLDGK 702  Rousettus bat coronav...
AWV67046   616 RLNQSCEFLRNLFQKLLSAFKTTTKWAGCAVEGIYTNAHCFFSRTGMLVEKQLKA.[2].LGFIFTPRQAKAEIEVLEGD 692  Bat coronavirus
AWV67062   627 RLNQSCEFLRTLFQKLLAVFKTTTKWAGCTVEGIYTNAHCFFSRTGMLVEKQLKA.[2].LGFIFTPKQVKSEIEVLEGE 703  Bat coronavirus
AWV67038   617 RLNQSCEFLRNLFQKLLSAFKTTTKWAGCAVEGIYTNAHCFFSRTGMLVEKQFKA.[2].LGFIFTPRQAKAEIEVLEGD 693  Bat coronavirus


Feature 1                                                                            
P0C6T6     703 FDAPVTLTDLELEECTGVLEEVFGASDVKLVKGTLVSLASKLFVRTEDGFLYRYVKSGGVLGKAFRLRGG 772  Rousettus bat coronavirus HKU9
ABN10934   703 PDAPVDLTNNELEEAHGTLEEVFGYSDLELVKGSLVTMASKVFVRTDDGVFYRYVRSGGVLLKAFRLRGG 772  Bat coronavirus HKU9-4
ADM33557   703 ADAPVELTSLELEELHGTLEEVFGYSDLGLVKGSLVTMASKVFVRTDDGVLYRYVKSGGVLLKAFRLRGG 772  Bat coronavirus HKU9-5-1
ADM33581   703 YDAPVTLTDLELEESTGVLEEVFGASDVKLVQGTLVSLASKLFVRTADGLFYRYVKSGGVLSKAFRLRGG 772  Bat coronavirus HKU9-10-2
AVP25405   703 PDAPVDLTNNELEEANGTLEEVFGYSDLALVKGSLVTMASKVFVRTEEGVFYRYVKSGGVLLKAFRLRGG 772  Rousettus bat coronavirus HKU9
QDF43839   702 YDAPVDLTTGELEDASGTLEEVFGSSDLALVKGSLVTMASKVFVRTEDGILYRYVREGGVLLKPFRLRGG 771  Coronavirus BtRt-BetaCoV/GX2018
AOG30811   703 YDAPVAITVPELEELNGTLEEVFGFDDLTLVRGSLVALASKVFVRTDDGLLFRYVKSGGVFLKAFRLRGG 772  Rousettus bat coronavirus
AWV67046   693 FDVPVELCSEEVDENAGTLEEVFGASDLQIVRGQLSVLASKLFVRTEEGLFYRYVSSGGVLLKAFRLRGG 762  Bat coronavirus
AWV67062   704 FDVPVELCSEEVDENAGTLEEVFGASDLQIVRGQLSVLASKLFVRTEEGLFYRYVSSGGVLLKAFRLRGG 773  Bat coronavirus
AWV67038   694 FDVPVELCSEEVDENAGTLEEVFGASDLQIVRGQLSVLASKLFVRTEEGLFYRYVSSGGVLLKAFRLRGG 763  Bat coronavirus

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