1Q7X,4XH7,1Y7N,2G2L,2HE2,1UIT,2IWO,1UEW,4OEP,1X8S,2OPG,1UM1,3CYY,1G9O,2DLU,2EDP,1L6O,2F5Y,1WFG,1N7E,1WH1,2FNE,1OBZ,1U3B,1Q3P,1Z87,2EGO,2LOB,2EJY,5E6P,1UEP,5F3X,1UEZ,2DKR,1WI2,2EEH,1UF1,1WFV,2W4F,1P1D,1IHJ,1B8Q,2ENO,6SAK,4WYT,1V62,1WHA,2KOJ,2YUY,2QT5,2KBS,2IWN,1UJU,4WYT,2EDV,1MFG,2QG1,1P1D,2D92,2DB5,2K1Z,2FCF,2AIN,6GBD,2YUB,3PS4,1RGR,3B76,1U3B,3HVQ,1UHP,2VZ5,1M5Z,2DAZ,2VSV,2VWR,1UFX,2CS5,2KV8,5F67,3SHW,1X6D,2I04,1UJV,1V6B,2QT5,6IRE,1WI4,1OBZ,2PA1,2PKU,6IRE,3GGE,5OAK,5ZYS,1N7F,5FB8


Conserved Protein Domain Family
PDZ_canonical
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cd00136: PDZ_canonical 
canonical PDZ domain
Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain. PDZ domains usually bind to short specific peptide sequences located at the C-terminal end of their partner proteins known as PDZ binding motifs. These domains can also interact with internal peptide motifs and certain lipids, and can take part in a head-to-tail oligomerization with other PDZ domains. The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. The canonical PDZ domain contains six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Links
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Statistics
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PSSM-Id: 467153
Aligned: 191 rows
Threshold Bit Score: 39.4482
Created: 27-Apr-2023
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
peptide binding
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on canonical PDZ domains with structure
  • Comment:PDZ domains specifically recognize and bind to short C-terminal peptide motifs, but can also recognize internal peptide motifs and certain lipids
  • Structure:1N7F: PDZ domain 6 of Rattus norvegicus glutamate receptor-interacting protein 1 (GRIP1) binds C-terminal peptide of liprin; contacts at 4A
    - View structure with Cn3D
  • Structure:5OAK: PDZ domain 1 of Drosophila melanogaster Par3 binds Drosophila melanogaster Par6 C-terminal peptide binding motif (PBM) peptide (VKDGVLHL); contacts at 4A
    - View structure with Cn3D
  • Structure:5ZYS: PDZ domain 3 of Mus musculus MAGI-1 binds nephrin PDZ-binding motif (PBM) peptide (LPFELRGHLV), contacts at 4A
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #######                   #  #                               #   #  #
1Q7X_A      12 EVELAKnd--nSLGISVTvlfdkggvntsvrhggIYVKAVIpqgaAESDg--rIHKGDRVLAVNGVSLegatHKQAVETL 87   human
1OBZ_A       7 EVILCKdq-dgKIGLRLKsid-----------ngIFVQLVQanspASLVg---LRFGDQVLQINGENCagwsSDKAHKVL 71   human
1WFV_A      14 TVDMEKga--kGFGFSIRggre--------ykmdLYVLRLAedgpAIRNg--rMRVGDQIIEINGESTrdmtHARAIELI 81   human
2EDV_A      11 TVKIDKdtllqDYGFHISes------------lpLTVVAVTag-gSAHGk---LFPGDQILQMNNEPAedlsWERAVDIL 74   human
2PA1_A       5 TVDVAGp---aPWGFRITggrd--------fhtpIMVTKVAergkAKDAd---LRPGDIIVAINGESAegmlHAEAQSKI 70   human
3GGE_A       8 EVNVYKse--dSLGLTITdng----------vgyAFIKRIKdggvIDSVk--tICVGDHIESINGENIvgwrHYDVAKKL 73   human
1N7F_A       8 TVELKRyg--gPLGITISgtee--------pfdpIIISSLTkgglAERTg--aIHIGDRILAINSSSLkgkpLSEAIHLL 75   Norway rat
A1ZA47       8 QIKLSRfd-aqPWGFRLQggtd--------faqpLLVQKVNagslSEQAg---LQPGDAVVKINDVDVfnlrHKDAQDIV 75   fruit fly
Q8TEW8     203 TVEISGeg--gPLGIHVVpffssl----sgrilgLFIRGIEdnsrSKREg--lFHENECIVKINNVDLvdktFAQAQDVF 274  human
O15018    1142 TVNLTGra-ndPCDLDSRvqat---------svkVTVAGFQpggaVEKEslgkLTTGDACVSTSCELAsalsHLDASHLT 1211 human

Feature 1      #             
1Q7X_A      88 RNtg--qVVHLLLE 99   human
1OBZ_A      72 KQaf-geKITMTIR 84   human
1WFV_A      82 KSgg--rRVRLLLK 93   human
2EDV_A      75 REae--dSLSITVV 86   human
2PA1_A      71 RQsp--sPLRLQLD 82   human
3GGE_A      74 KElkkeeLFTMKLI 87   human
1N7F_A      76 QMag--eTVTLKIK 87   Norway rat
A1ZA47      76 VRsg--nNFVITVQ 87   fruit fly
Q8TEW8     275 RQamkspSVLLHVL 288  human
O15018    1212 ENlp--kAASELGQ 1223 human

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