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Conserved domains on  [gi|2708105425|gb|WYM45472|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Canis lupus familiaris]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-175 9.72e-88

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 254.34  E-value: 9.72e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2708105425   1 MMTYIVFILSIVFVMSFVGFATKPSPIYGGLVLIISGGIGCAIVLNFGGSFLGLM*******GMLVVFGYTIAMATEQYP 80
Cdd:MTH00109    1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2708105425  81 EVWVSNKAVLAAFITGLLSELLTACYILKDDEVEVVLKFNGMGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVVVTGWS 160
Cdd:MTH00109   81 ETWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                         170
                  ....*....|....*
gi 2708105425 161 LLIGVLVIMEVTRGN 175
Cdd:MTH00109  161 LFIGVFVIIEITRGN 175
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-175 9.72e-88

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 254.34  E-value: 9.72e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2708105425   1 MMTYIVFILSIVFVMSFVGFATKPSPIYGGLVLIISGGIGCAIVLNFGGSFLGLM*******GMLVVFGYTIAMATEQYP 80
Cdd:MTH00109    1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2708105425  81 EVWVSNKAVLAAFITGLLSELLTACYILKDDEVEVVLKFNGMGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVVVTGWS 160
Cdd:MTH00109   81 ETWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                         170
                  ....*....|....*
gi 2708105425 161 LLIGVLVIMEVTRGN 175
Cdd:MTH00109  161 LFIGVFVIIEITRGN 175
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-170 4.29e-06

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 44.03  E-value: 4.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2708105425  18 VGFATKPSPIYGGLVLIISGGIGCAIVLNFGGSFLGLM*******GMLVVFGYTIAMATEQYPEVWVSNKAVLAAFITGL 97
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2708105425  98 LseLLtacyilkddeVEVVLKFNGMGDWVIYDTGDSGFFSEEAMGIaALYSYGTWLVVVTGWSLLIGVLVIME 170
Cdd:pfam00499  81 L--LL----------ALLLLVLLSASLTPAAAAAAPDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIV 140
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-175 9.72e-88

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 254.34  E-value: 9.72e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2708105425   1 MMTYIVFILSIVFVMSFVGFATKPSPIYGGLVLIISGGIGCAIVLNFGGSFLGLM*******GMLVVFGYTIAMATEQYP 80
Cdd:MTH00109    1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2708105425  81 EVWVSNKAVLAAFITGLLSELLTACYILKDDEVEVVLKFNGMGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVVVTGWS 160
Cdd:MTH00109   81 ETWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                         170
                  ....*....|....*
gi 2708105425 161 LLIGVLVIMEVTRGN 175
Cdd:MTH00109  161 LFIGVFVIIEITRGN 175
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 2-174 9.69e-25

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 94.05  E-value: 9.69e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2708105425   2 MTYIVFILSIVFVMSFVGFATKPSPIYGGLVLIISGGIGCAIVLNFGGSFLGLM*******GMLVVFGYTIAMATEQYPE 81
Cdd:MTH00138    1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2708105425  82 VWVSNkAVLAAFITGLLSELLTACYILKDdevevvlkfNGMGDWVI-YDTGDSGFFSEEAMGIAALYSYGTWLVVVTGWS 160
Cdd:MTH00138   81 SWGSW-SVLGYVVGYLVGVVLAAGLFWGG---------WYEGSWVVvDELKEFSVLRGDVGGVALMYSSGGGMLVICAWV 150

                         170
                  ....*....|....
gi 2708105425 161 LLIGVLVIMEVTRG 174
Cdd:MTH00138  151 LLLTLFVVLELTRG 164
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 2-174 4.29e-23

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 89.91  E-value: 4.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2708105425   2 MTYIVFILSIVFVMSFVGFATKPSPIYGGLVLIISGGIGCAIVLNFGGSFLGLM*******GMLVVFGYTIAMATEQYPE 81
Cdd:MTH00065    1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2708105425  82 VWVSNKAVLAAFITGLlseLLTACYILKDDEVEVVLKFNGMGDWViydtgdsGFFSEEAMGIAALYSYGTWLVVVTGWSL 161
Cdd:MTH00065   81 AWGSWSVLVYVLFYLL---LLIVGYILFGCNFSLEFLFTNYDTEF-------SVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                         170
                  ....*....|...
gi 2708105425 162 LIGVLVIMEVTRG 174
Cdd:MTH00065  151 LLTLFVVLEVTRG 163
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 2-174 6.98e-18

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 76.33  E-value: 6.98e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2708105425   2 MTYIVFILSIVFVMSFVGFATKPSPIYGGLVLIISGGIGCAIVLNFGGSFLGLM*******GMLVVFGYTIAMATEQYPE 81
Cdd:MTH00115    1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2708105425  82 VWVSNKAVLAAFITGLLSELLTACYilkddeveVVLKFNGMGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVVVTGWSL 161
Cdd:MTH00115   81 AWGDWGVVGYVVGFVLVVVVVGVVV--------GGLWGMEGVGVVTVDSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                         170
                  ....*....|...
gi 2708105425 162 LIGVLVIMEVTRG 174
Cdd:MTH00115  153 LLTLFVVLELVRG 165
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 2-174 2.62e-12

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 61.54  E-value: 2.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2708105425   2 MTYIVFILSIVFVMSFVGFATKPSPIYGGLVLIISGGIGCAIVLNFGGSFLGLM*******GMLVVFGYTIAMATEQYPE 81
Cdd:MTH00214    1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2708105425  82 VWVSNKAVLAAFITGLLSELLTACYIlkddevevvlkfngMGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVVVTGWSL 161
Cdd:MTH00214   81 SWGGWSVLLFFLFYLLGLGFVGFYFY--------------GGWEMLSWMGVDEANNLDLSGVSDLYSRGFFLLLLGGVVL 146

                         170
                  ....*....|...
gi 2708105425 162 LIGVLVIMEVTRG 174
Cdd:MTH00214  147 FLVLFVVLELVRG 159
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-175 6.34e-08

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 49.52  E-value: 6.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2708105425   1 MMTYIVFILsIVFVMSFVGFATkpSPIYGGLVLIISGGIGCAIVLNFGGSFLGLM*******GMLVVFGYTIAMATEQYP 80
Cdd:MTH00045    1 MVFYLFLIL-MLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2708105425  81 EVWVSNKAVLAAFITGLLselltacyilkddeveVVLKFNGMGDWVIYDTGDSGFFSEeaMGIAALYSYGTWLVVVTGWS 160
Cdd:MTH00045   78 SVSNLGEVLVLSLLLSLW----------------VFISFDNFLELSNNNWSLVSLSDL--VGSSELYNSGGLYLLLGGFI 139

                         170
                  ....*....|....*
gi 2708105425 161 LLIGVLVIMEVTRGN 175
Cdd:MTH00045  140 LLVALVVALVISFGH 154
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-170 4.29e-06

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 44.03  E-value: 4.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2708105425  18 VGFATKPSPIYGGLVLIISGGIGCAIVLNFGGSFLGLM*******GMLVVFGYTIAMATEQYPEVWVSNKAVLAAFITGL 97
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2708105425  98 LseLLtacyilkddeVEVVLKFNGMGDWVIYDTGDSGFFSEEAMGIaALYSYGTWLVVVTGWSLLIGVLVIME 170
Cdd:pfam00499  81 L--LL----------ALLLLVLLSASLTPAAAAAAPDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIV 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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