| NCBI National Center for Biotechnology Information |  |
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5HHW:
Crystal structure of insulin receptor kinase domain in complex with cis-(R)-7-(3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-((tetrahydro-2H-pyran-2-yl)methoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
| Biological unit 1: | monomeric |
| Source organism: | Homo sapiens |
| Number of proteins: | 1 (Insulin receptor) |
| Number of chemicals: | 2 (7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2... ▼)
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Similar Structures (5401)
Showing 1 to 10 out of 5401 selected structures
| PDB ID | Description | Taxonomy | Aligned Protein | RMSD | Aligned Residues | Sequence Identity | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Full |
4IBM | Crystal structure of insulin receptor kinase domain in complex with an inhibitor Irfin-1 |
Homo sapiens |
1 | 1.72Å | 299 | 99% | |
| 2 | Full |
1IRK | CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR |
Homo sapiens |
1 | 1.52Å | 295 | 99% | |
| 3 | Full |
5FXS | IGFR-1R complex with a pyrimidine inhibitor |
Homo sapiens |
1 | 1.92Å | 295 | 79% | |
| 4 | Full |
1P4O | Structure of Apo unactivated IGF-1R KInase domain at 1.5A resolution |
Homo sapiens |
1 | 1.56Å | 293 | 78% | |
| 5 | Full |
3NW5 | Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a carbon-linked proline isostere inhibitor (11B) |
Homo sapiens |
1 | 1.78Å | 293 | 80% | |
| 6 | Full |
4D2R | Human IGF in complex with a Dyrk1B inhibitor |
Homo sapiens |
1 | 1.75Å | 292 | 80% | |
| 7 | Full |
3NW7 | Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a carbon-linked proline isostere inhibitor (34) |
Homo sapiens |
1 | 1.83Å | 292 | 80% | |
| 8 | Full |
3I81 | Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with BMS-754807 [1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoro-3-pyridinyl)-2-methyl-L-prolinamide] |
Homo sapiens |
1 | 1.98Å | 292 | 80% | |
| 9 | Full |
3ETA | Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor |
Homo sapiens |
1 | 1.48Å | 291 | 99% | |
| 10 | Full |
3NW6 | Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a carbon-linked proline isostere inhibitor (11A) |
Homo sapiens |
1 | 1.65Å | 291 | 80% |
